{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:56:18Z","timestamp":1781002578143,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acrylamide (ACR) is a hazardous chemical pollutant due to thermal processing of certain foods. This study aimed to profile the metabolites of the methanolic extract of <jats:italic>Cucurbita pepo<\/jats:italic> L. (Cucurbitaceae) aerial parts against nephrotoxicity induced by ACR in rats. GC\/MS and LC\u2013ESI\u2013MS\/MS analysis were used for isolation and differentiation of different metabolites. In silico study was done on the identified triterpenes and sterols. In vivo nephrotoxicity was done by intraperitoneal injection of ACR to rats. Serum kidney function tests, oxidative stress, inflammatory markers, and histopathological observation were evaluated. Twenty\u2010four compounds were identified, where stigmasterol and \u03b2\u2010sitosterol were the most prevalent metabolites. Fifty\u2010one compounds in positive and negative modes were also identified. Four compounds were isolated: stigmasterol, \u03b2\u2010sitosterol, <jats:italic>p<\/jats:italic>\u2010coumaric, and <jats:italic>p<\/jats:italic>\u2010hydroxybenzoic. Cucurbitacin A 2\u2010<jats:italic>O<\/jats:italic>\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranoside and karaviloside XIII possessed anti\u2010inflammatory and antioxidant effects by in silico study. Treatment with <jats:italic>C. pepo<\/jats:italic> L. aerial parts methanolic extract restored the levels of creatinine (Cr), blood urea nitrogen (BUN), kidney injury molecule\u20101 (KIM\u20101), malondialdehyde (MDA), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), superoxide dismutase (SOD), and glutathione (GSH). In conclusion, <jats:italic>C. pepo<\/jats:italic> L. leaves methanolic extract possessed curative effect against ACR toxicity due to its richness with different bioactive compounds.<\/jats:p>","DOI":"10.1002\/cbdv.202402856","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T03:34:21Z","timestamp":1742441661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GC\/MS and LC\u2013ESI\u2013MS\/MS Analysis of <i>Cucurbita pepo<\/i> L. Aerial Parts Methanolic Extract via Regulating Oxidative Stress and Inflammatory Mediators Against Acrylamide\u2010Induced Nephrotoxicity in Rats Supported by In Silico Investigations"],"prefix":"10.1002","author":[{"given":"Enaam M.","family":"AbouZeid","sequence":"first","affiliation":[{"name":"Pharmacognosy Department National Research Centre, Dokki  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Elbatanony","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department National Research Centre, Dokki  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yomna R.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre, Dokki  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-5842","authenticated-orcid":false,"given":"Manal A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre, Dokki  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1573407216999200918182514","article-title":"Therapeutic Potential of Citrus sinensis Peels Against Rotenone Induced Parkinsonism in Rats","volume":"17","author":"Hamed M.","year":"2021","journal-title":"Current Bioactive Compounds"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/22311866.2022.2081607","article-title":"Phytoconstituents of Red Grape Seeds Extract and Interleukin\u20101 Receptor Antagonist as Inflammatory Regulators in Adjuvant Arthritic Rats","volume":"12","author":"Hamed M. 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