{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:09:03Z","timestamp":1780319343314,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Zinc (Zn) ions play a crucial role in cancer therapy due to their ability to induce reactive oxygen species (ROS) generation, oxidative stress, and ferroptosis. Combining Zn ions with other therapeutic agents can significantly enhance their efficacy through synergistic mechanisms. This study explores the synergistic mechanism of Zn ions from pH\u2010responsive ZIF\u20108 and repurposed drug pimozide in tumor microenvironment mimic conditions. The synthesized ZIF\u20108 exhibited an average size distribution of 36\u00a0nm with 52.21\u00a0\u00b1\u00a01.86% encapsulation efficiency for pimozide. Notably, the maximum drug release of 84.13% was observed at pH 6. Furthermore, in vitro cytotoxicity investigations revealed heightened efficacy of pimozide\u2013ZIF\u20108 formulations after 48\u00a0h of treatment. In addition, pimozide\u2013ZIF\u20108 concomitantly induced ferroptosis and apoptosis in MCF\u20107 cells at pH 6, underscoring the pharmacological potency of the composite structure. Complementary to these experimental findings, an in silico network analysis was performed to uncover protein interaction networks of Zn ions and pimozide, highlighting their multi\u2010targeted action in cancer\u2010related pathways. Altogether, this dual\u2010action approach activates both ferroptosis and apoptosis, presenting a promising therapeutic strategy for breast cancer that offers enhanced efficacy and targeting through the combined effects of Zn ions and pimozide.<\/jats:p>","DOI":"10.1002\/cbdv.202402883","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:17:59Z","timestamp":1741681079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Therapeutic Effects of Zn Ions and Pimozide in Breast Cancer Cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Thirukumaran","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-0936","authenticated-orcid":false,"given":"Siddhartha Sankar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Guwahati  Guwahati Assam India"},{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/2Ffphar.2024.1333543"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215535"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201003482\u20105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102384\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2021.111445"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2024.134288"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112567"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13111779"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813689-8.00005-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012786\u20106"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121785"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00159"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27016-6_6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909115612800"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.38"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30574"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113063"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/2Ffmolb.2020.00193"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010019\u201004965\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc05002d"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602439103"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CE42485E"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07089D"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201902599"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/2Fd0ra10423j"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/2Foncotarget.27951"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010197612010\u201000001"}],"container-title":["Chemistry &amp; 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