{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:54:27Z","timestamp":1773280467260,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Copaiba oleoresin is one of the most popular medicines in the Amazon.\n                    <jats:italic>Ent<\/jats:italic>\n                    \u2010polyalthic acid (PA) is one of the diterpenes found in the oleoresin and has been shown to have several biological activities including antimicrobial, antifungal, antiparasitic, and many others. Therefore, it could be used as a lead compound in the development of new drugs. This review describes in vitro and in vivo biological activities, and the mechanisms of action of PA reported in the literature. Although there are several studies, the majority reported the results of in vitro studies. Effects in humans are nonexistent since PA has not been tested in any clinical trials.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402894","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T12:13:41Z","timestamp":1738325621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Biological Activities of\n                    <i>Ent<\/i>\n                    \u2010Polyalthic Acid"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-1662","authenticated-orcid":false,"given":"Cassia S.","family":"Mizuno","sequence":"first","affiliation":[{"name":"College of Pharmacy and Health Sciences Western New England University  Springfield Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Alves dos Santos","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca, Av. Dr. Armando Salles de Oliveira  Franca Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Nascimento Silveira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca, Av. 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O.Igoli O. G.Ogaji T. A.Tor\u2010Ayiin andN. P.Igoli Traditional Medicine Practice Amongst the Igede People of Nigeria. Part II 2005.","DOI":"10.4314\/ajtcam.v2i2.31112"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8350320"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.062"},{"key":"e_1_2_9_19_1","unstructured":"N.Villa\u2010Ruano E.Lozoya\u2010Gloria andY.Pacheco\u2010Hern\u00e1ndez Kaurenoic Acid. In: Studies in Natural Products Chemistry [Internet]. Elsevier; 2016 [cited 2024 Mar 23]. p: 151\u201374. 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