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The most potent compound in the series outperformed tamoxifen and 5\u2010fluorouracil, with selectivity indices of 1.60 and 1.99 against MDA\u2010MB\u2010468 and MDA\u2010MB\u2010231 cancer cells, respectively. The Caspase 3\/7 7\u2010AAD assay showed live cell populations of 72.10% and 49.20% after 24 and 48\u00a0h, respectively, indicating that the cytotoxic effect is mediated through the caspase apoptotic pathway. Molecular docking studies further suggested the compound's potential as an epidermal growth factor receptor inhibitor, highlighting its promise as a therapeutic agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402910","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:48:32Z","timestamp":1733791712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, Synthesis, Anti\u2010Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole\u2013Isatin Hybrids on Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","volume":"22","author":[{"family":"Preeti","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Nanak Dev University  Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Penn State Cancer Institute The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni Kant","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Basic Science &amp; Humanities CCS Haryana Agricultural University  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Penn State Cancer Institute The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-7161","authenticated-orcid":false,"given":"Vipan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Nanak Dev University  Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cancer Today","author":"Global Cancer Observatory, International Agency for Research on Cancer, World Health Organization","year":"2023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.ijmr_1145_21"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30447-9"},{"key":"e_1_2_8_5_1","unstructured":"World Health Organization World Health Statistics 2022: Monitoring Health for the SDGs Sustainable Development Goals. 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