{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:17:40Z","timestamp":1762255060752,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Desmodium gyrans<\/jats:italic> DC (Fabaceae) has been widely used in Indian and Chinese traditional medicine as a cardiotonic and for wound healing. There is not much scientific literature supporting the medicinal use of the plant. The present study aimed to evaluate the cardioprotective effect of the methanolic extract of <jats:italic>D. gyrans<\/jats:italic> in rats. The objective of the study is to validate the use of the plant in traditional medicine. The cardioprotective effect of this plant was studied in Sprague Dawley rats by separately inducing cardiomyopathy and myocardial infarction using doxorubicin (DOX) and isoproterenol (ISO), respectively. Variations in serum cardiac markers, antioxidants, and lipid peroxidation levels in cardiac tissue were analyzed. Antioxidant status was also studied in the cardiac mitochondrial fraction. A histopathological examination of heart tissue was done. The results indicated a significant increase in the lipid peroxidation products with a concomitant reduction in the tissue antioxidant enzymes activities (SOD and GPx) and glutathione levels in DOX and ISO alone treated rats. However, treatment of the rats with <jats:italic>D. gyrans<\/jats:italic> restored the redox balance in the cardiac tissues of these rats. Overall, the results showed that the methanolic extract of <jats:italic>D. gyrans<\/jats:italic> has significant protective activity against ISO\u2010induced myocardial infarction and moderate protection against DOX\u2010induced cardiomyopathy.<\/jats:p>","DOI":"10.1002\/cbdv.202402951","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T22:19:43Z","timestamp":1747779583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Analysis and Protective Effect of <i>Desmodium gyrans<\/i> DC in Doxorubicin\u2010induced Cardiomyopathy and Isoproterenol\u2010induced Myocardial Infarction"],"prefix":"10.1002","author":[{"given":"Vipin P.","family":"Sivaram","sequence":"first","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"},{"name":"Department of Biochemistry Government Arts and Science College (Affiliated to University of Calicut)  Palakkad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannah N.","family":"Mulakkal","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"},{"name":"Department of Zoology Kodungallur Kunjikuttan Thampuran Memorial Government College (Affiliated to University of Calicut)  Thrissur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lincy","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alfarhan","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology College of Science, King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajakrishnan","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology College of Science, King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-1665","authenticated-orcid":false,"given":"Arunaksharan","family":"Narayanankutty","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"},{"name":"Division of Cell and Molecular Biology PG and Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Affiliated to University of Calicut  Kozhikode India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Padikkala","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry Amala Cancer Research Centre  Thrissur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"8","article-title":"Evaluation of Antimicrobial Activity of the Fruits of Cucumis trigonus Roxb","volume":"3","author":"Gopalakrishnan S.","year":"2012","journal-title":"International Research Journal of Pharmacy"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.09.053"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.028"},{"volume-title":"Indian Medicinal Plants","year":"1995","author":"Warrier P. 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