{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:48:19Z","timestamp":1773013699788,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemical investigation of the mangrove\u2010derived fungus\n                    <jats:italic>Trichoderma<\/jats:italic>\n                    sp. GXT\u201022.1 led to the isolation and identification of 10 secondary metabolites, including one new compound, 5\u2032\u2010(4\u2010methoxyphenyl)\u20101\u2032,3\u2032\u2010oxazole (\n                    <jats:bold>1<\/jats:bold>\n                    ), one new natural compound, (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20106,10\u2010dimethyl\u20105\u2010undecene\u20102,9,10\u2010triol (\n                    <jats:bold>2<\/jats:bold>\n                    ), along with eight known compounds, tricholumin A (\n                    <jats:bold>3<\/jats:bold>\n                    ), harzianol J (\n                    <jats:bold>4<\/jats:bold>\n                    ), cyclonerodiol (\n                    <jats:bold>5<\/jats:bold>\n                    ), 10,11\u2010dihydro\u201011\u2010hydroxycyclonerodiol (\n                    <jats:bold>6<\/jats:bold>\n                    ), cyclonerodiol B (\n                    <jats:bold>7<\/jats:bold>\n                    ), epicyclonerodiol oxide (\n                    <jats:bold>8<\/jats:bold>\n                    ), cyclo(Val\u2010Pro) (\n                    <jats:bold>9<\/jats:bold>\n                    ), and cyclo\u2010(4\u2010hydroxyprolinyl\u2010leucine) (\n                    <jats:bold>10<\/jats:bold>\n                    ). The structural feature of oxazole in\n                    <jats:bold>1<\/jats:bold>\n                    was unusually found among the fungal metabolites. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    exhibited weak cytotoxicity toward HepG2 and MCF\u20107 human carcinoma cell lines at the concentration of 100\u00a0\u00b5M, with induction of 41.5 \u00b1 3.0% and 39.3 \u00b1 2.3% cell death, respectively. Compounds\n                    <jats:bold>1\u22125, 8,<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    showed their inhibitory effect against nitric oxide (NO) overproduction in lipopolysaccharide\u2010stimulated RAW264.7 cells, with half inhibition concentration values ranging from 37.5 \u00b1\u00a02.6 to 86.5 \u00b1\u00a05.1\u00a0\u00b5M. Molecular docking simulation suggested that\n                    <jats:bold>1<\/jats:bold>\n                    inhibits NO overproduction via modulating the action of the inducible NO synthase protein.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402986","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T11:29:41Z","timestamp":1734089381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Oxazole Alkaloid, Terpenoids, and Cyclodipeptides With Cytotoxic and Nitric Oxide Inhibitory Effects From a Mangrove\u2010Derived Fungus\n                    <i>Trichoderma<\/i>\n                    sp. GXT\u201022.1"],"prefix":"10.1002","volume":"22","author":[{"given":"Dang Viet","family":"Anh","sequence":"first","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoang","family":"Anh","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi","family":"Vien","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Thi Mai","family":"Huong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Xuan","family":"Cuong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Thanh","family":"Ngan","sequence":"additional","affiliation":[{"name":"Institute of Genome Research Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Ngoc","family":"Tung","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-5271","authenticated-orcid":false,"given":"Tran Hong","family":"Quang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.12.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.791033"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1315395"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100059m"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00344"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c04540"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9030058"},{"key":"e_1_2_8_9_1","article-title":"Bioactive Secondary Metabolites From Trichoderma spp. Against Phytopathogenic Fungi","volume":"8","author":"Khan R. 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