{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:11:53Z","timestamp":1791598313954,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    New Cd(II), Zn(II), and Cu(II) chelates with cetirizine.2HCl (CETZ.2HCl) in incidence of 1,10 phenanthroline monohydrate (Phen.H\n                    <jats:sub>2<\/jats:sub>\n                    O) were synthesized in search of new biologically active compounds. The ligands and their chelates were described by 1H NMR, FT\u2010IR, elemental analysis, UV\u2013vis spectrophotometry, thermal analyses, molar conductance, x\u2010ray diffraction (XRD), and magnetic\u2010susceptibility measurements. FT\u2010IR demonstrated that CETZ.2HCl is bonded with metal ions, as a monodentate via carboxylate oxygen atom and Phen.H\n                    <jats:sub>2<\/jats:sub>\n                    O chelated via two nitrogen atoms. The molar conductivity data showed that the complexes were nonelectrolytes, whereas XRD data supported that the compounds were crystalline. Density functional theory (DFT) was utilized to gain insight into the compounds' optimized design. The effects of CETZ.2HCl and the complexes on the activity of lipoprotein\u2010(L)\u2010lipase in mice were investigated. Unlike Cd(II) complex, all the other compounds exhibited significant increase in lipase activity, with reduction in triglycerides. Cu(II) and Zn(II) complexes showed robust hypolipidemic efficacy evidenced by lower levels of total cholesterol and low\u2010density lipoprotein (LDL), concomitant with higher levels of high\u2010density lipoprotein (HDL). Furthermore, Zn(II) complex was a safe alternative as it has a lower liver toxicity. Molecular docking demonstrated that Cu(II) and Zn(II) chelates exhibited greater affinities to lipase than the parent ligand. Finally, Cu(II) complex showed the highest antibacterial activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403003","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T15:29:51Z","timestamp":1734103791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Structural, Spectroscopic, and Docking Analysis of N,O\u2010Donor Ligand Metal Complex Nanoparticles With Hypolipidemic Effects via Lipoprotein Lipase Activation in High\u2010Fat Diet Mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Sherif M.","family":"Abd El\u2010Hamid","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories Technology College of Health and Medical Technologies Al\u2010Ayen Iraqi University (AUIQ)  Thi\u2010Qar Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa W.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Clinical Sciences College of Pharmacy University of Babylon  Babylon Babil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Basic Science Zagazig Higher Institute of Engineering and Technology  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"El\u2010Gedamy","sequence":"additional","affiliation":[{"name":"Department of Clinical biochemistry and Molecular biology Urology and Nephrology Center  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Egyptian Mineral Resources Authority (EMRA)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha F.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael A.","family":"Zordok","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Sofo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Forestry, Food and Environmental Sciences University of Basilicata  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Sabry","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeek A.","family":"Sadeek","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-7319","authenticated-orcid":false,"given":"Hazem S.","family":"Elshafie","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Forestry, Food and Environmental Sciences University of Basilicata  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.11.077"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973\u2010015\u20105057\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.07.095"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051480"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4889"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122831"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC134.365"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.9.1565"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398\u20109995.1999.00032.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.11.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.03.070"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.05.029"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2014.994513"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.10.051"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.04.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2005.07.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10953\u2010015\u20100362\u20109"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051027"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7129"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7337-6_21"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.07.047"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2013.839027"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2011.587004"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5155\/eurjchem.4.4.370\u2010378.803"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2013.05.022"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.11.012"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2011.12.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122149"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7362"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091198"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.01.035"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12423"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1786129"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.07.022"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00027.2014"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215590451"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.10.007"},{"key":"e_1_2_9_41_1","unstructured":"M. J.Frisch et\u00a0al. Gaussian c98 Revision A.6 Inc. Pittsburgh PA(1998)."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.140.A1133"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.38.3098"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1103\/physrevb.37.785"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010\u20108545(00)80437\u20103"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268979300103121"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12070690"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042110"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.123274"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6958"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201042550\u2010y"},{"key":"e_1_2_9_52_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US)","year":"2011"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.60.5.1646\u20101651.1994"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1094\/PD\u201077\u20100985"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2004.04.017"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109948"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsfoodscitech.1c00415"},{"key":"e_1_2_9_58_1","volume-title":"BIOVIA Discovery Studio Academic Research Suite","author":"Biovia D. S.","year":"2021"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181798411"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7650"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.121404"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/compounds3030029"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114560"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2008.08.018"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2011.09.010"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2007.05.042"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138115"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.03.085"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.03.013"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6178"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122460"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2012.10.058"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10953\u2010015\u20100362\u20109"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6715"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1515\/chem\u20102021\u20100063"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.08.031"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1070328407060073"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1081\/SIM\u2010100002053"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.05.011"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2010.514049"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5334"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.21608\/EJCHEM.2021.56086.3211"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/15533174.2013.862686"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4347"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics10110177"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2010.05.041"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2007.01.015"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2016.05.101"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/201068a0"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60203a013"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973\u2010008\u20109342\u20102"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2019.01.042"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7539"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2014.11.022"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.01.019"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7460"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7290"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6576"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.46.5.1607\u20101609.2002"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.01.030"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_9_102_1","unstructured":"PreADMET An Online ADMET Properties Predictor accessed May 4 2023 https:\/\/preadmet.webse0072vice.bmdrc.org\/."},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0482278"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp0307607"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20102614(96)00440\u2010X"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202403003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:30:41Z","timestamp":1773009041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202403003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cbdv.202403003"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202403003","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202403003"}}