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Renal fibrosis is the hallmark of end\u2010stage kidney disease (ESKD), which can progress to death. The super\u2010fuels for renal fibrosis are oxidative stress and inflammation. It occurs almost without exception in all CKD patients, but how it develops is still ambiguous. Flavonoids demonstrate tremendous fighting power against inflammation and oxidative stress in many diseases. NF\u2010\u03baB suppression has been deeply investigated in renal fibrosis, with phenomenally good outcomes. This review shed light on flavonoids\u2019 ability to beat renal fibrosis associated with NF\u2010\u03baB activation. Flavonoids\u00a0such as apigenin, baicalin, diosmin, epigallocatechin\u20103\u2010gallate, genistein, isoliquiritigenin, naringin, puerarin, quercetin, silibinin, wogonin, biochanin A, and cardamonin exhibit promising antifibrotic effects through targeting NF\u2010\u03baB. Moreover, in silico studies showed that flavonoids displayed an outstanding inhibitory effect on NF\u2010\u03baB based on the energy of binding. They are well\u2010fitted to the binding pocket of the target protein by forming hydrogen bonds, hydrophobic, and ionic interactions with the key amino acid residues. The outcomes revealed that silibinin, baicalin, and baicalein are the most powerful NF\u2010\u03baB inhibitors. In conclusion, through suppressing NF\u2010\u03baB signal, flavonoids display a dynamite performance in combating CKD and renal fibrosis.<\/jats:p>","DOI":"10.1002\/cbdv.202403022","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T22:22:51Z","timestamp":1739226171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Flavonoids in Combating Renal Fibrosis: Targeting NF\u2010\u03baB Signal and In Silico Support"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-7217","authenticated-orcid":false,"given":"Haitham","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy Al\u2010Azhar University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan S.","family":"Althagafy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science University of Jeddah Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa S. 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