{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:25:55Z","timestamp":1786317955272,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We aimed to determine the relaxant pathway of seventeen synthetic compounds derived from coumarin\u20103\u2010carboxamide. An isolated rat aorta assay was used. To determine the vasorelaxant mode of action, receptor blockers and specific enzyme inhibitors involved in endothelial and smooth muscle signaling pathways were used. The compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    showed higher activity than the other compounds.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010nitro\u2010L\u2010arginine methyl ester (10\u00a0\u00b5M) and methylene blue (10\u00a0\u00b5M) significantly inhibited the relaxant effect of the compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2264 0.05), but not tetraethylammonium (5\u00a0mM), indomethacin (10\u00a0\u00b5M), or atropine (1\u00a0\u00b5M). The compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    abated the contraction induced by CaCl\n                    <jats:sub>2<\/jats:sub>\n                    . The compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    exert a relaxing effect through the nitric oxide\/cyclic guanosine monophosphate pathway activation and by blocking Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels of the cell membrane. These findings propose coumarin\u20103\u2010carboxamides as new drug entities with the potential to develop non\u2010clinical and clinical.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403028","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T22:20:01Z","timestamp":1738362001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Relaxant Effect of Coumarin\u20103\u2010carboxamides Through the Nitric Oxide\/Cyclic Guanosine Monophosphate Pathway and Ca\n                    <sup>2+<\/sup>\n                    Channels Blockade"],"prefix":"10.1002","volume":"22","author":[{"given":"Arabelly","family":"Jim\u00e9nez\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica y Productos Naturales Centro de Investigaci\u00f3n de Ciencia y Tecnolog\u00eda Aplicada de Tabasco (CICTAT) Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Cunduac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuauht\u00e9moc","family":"Alvarado\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica y Productos Naturales Centro de Investigaci\u00f3n de Ciencia y Tecnolog\u00eda Aplicada de Tabasco (CICTAT) Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Cunduac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Velasco","sequence":"additional","affiliation":[{"name":"Complejo Regional Mixteca Campus Chiautla de Tapia Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Chiautla de Tapia Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estephania","family":"L\u00f3pez\u2010Oliva","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica y Productos Naturales Centro de Investigaci\u00f3n de Ciencia y Tecnolog\u00eda Aplicada de Tabasco 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