{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:57:28Z","timestamp":1755226648358,"version":"3.43.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to determine the phytochemical composition of the essential oil (EO) from <jats:italic>Brunfelsia uniflora<\/jats:italic> leaves and to evaluate its antifungal and cytotoxic activities. The EO was obtained by hydrodistillation and analyzed using GC\u2010MS and GC\u2010FID, leading to the identification of 39 compounds. The composition was predominantly terpenoid (65.7%), followed by non\u2010terpenoid constituents (31.2%). The major compounds identified included phytol (13.2%), oleic acid (10.5%), phenylethyl alcohol (9.2%), and \u03b3\u2010eudesmol acetate (7.0%). The antifungal activity of the EO was evaluated against <jats:italic>Candida<\/jats:italic> species using the broth microdilution method. The EO exhibited strong inhibitory effects against <jats:italic>C. albicans<\/jats:italic> and <jats:italic>C. orthopsilosis<\/jats:italic> (MIC\u00a0=\u00a062.5\u00a0\u00b5g\/mL), moderate activity against <jats:italic>C. glabrata<\/jats:italic> and <jats:italic>C. rugosa<\/jats:italic> (MIC\u00a0=\u00a0250\u00a0\u00b5g\/mL), and weak activity against <jats:italic>C. tropicalis<\/jats:italic> (MIC\u00a0=\u00a01000\u00a0\u00b5g\/mL). The cytotoxic effects of the EO were assessed in human tumor cell lines (HeLa, MCF\u20107) and a nontumor fibroblast line (GM07492A). The EO demonstrated selective cytotoxicity toward HeLa (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a021.9\u00a0\u00b5g\/mL) and MCF\u20107 (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a025.7\u00a0\u00b5g\/mL), while exhibiting lower toxicity to fibroblasts (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a0131.9\u00a0\u00b5g\/mL). The selectivity indices (SI\u00a0=\u00a06.0 for HeLa, 5.1 for MCF\u20107) suggest its potential as a promising therapeutic candidate for antifungal and anticancer applications.<\/jats:p>","DOI":"10.1002\/cbdv.202403029","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T22:30:53Z","timestamp":1743719453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition, Antifungal, and Cytotoxic Activities of Essential Oil From <i>Brunfelsia uniflora<\/i> Leaves"],"prefix":"10.1002","author":[{"given":"I. F.","family":"Francisco","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Carlos Araras Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso Cuiab\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. M.","family":"Mazza","sequence":"additional","affiliation":[{"name":"Universidade de Franca Franca Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H","family":"Pires","sequence":"additional","affiliation":[{"name":"Universidade de Franca Franca Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Universidade de Franca Franca Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Universidade de Franca Franca Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C.","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-0394","authenticated-orcid":false,"given":"V. C. 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