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Their structures, including absolute configurations, were unambiguously elucidated by HR\u2010ESI\u2013MS, extensive NMR spectroscopy, and quantum chemical calculation of electronic circular dichroism (ECD) method. Moreover, the anti\u2010neuroinflammation activities of isolated compounds were evaluated. As a result, Compounds\n                    <jats:bold>1\u20132<\/jats:bold>\n                    decreased the production of nitric oxide (NO) in LPS\u2010stimulated mouse BV2 microglia. Further mechanism study indicated that\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exerted anti\u2010neuroinflammation effects by suppressing the expression of pro\u2010inflammatory enzymes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)\u20102. Above all, compounds\n                    <jats:bold>1\u20132<\/jats:bold>\n                    showed promise as useful therapeutic agents in the treatment of neurodegenerative diseases caused by neuroinflammation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403037","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:35:13Z","timestamp":1734395713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypersine H, One Undescribed Xanthone From the\n                    <i>Hypericum elodeoides<\/i>\n                    Choisy With Anti\u2010Neuroinflammation Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Shoulun","family":"He","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences Xiamen University  Xiamen 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School of Pharmaceutical Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiling","family":"Sun","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Ding","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian 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