{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:43Z","timestamp":1753862803719,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Psychotria adenophylla<\/jats:italic> Wall. (Rubiaceae) is a promising plant with potential drug molecules. In this study, ethanolic leaf extracts were utilized for antioxidant (DPPH, FRAP, and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> methods) and metabolomic (GC\u2013MS and FTIR) and potential, evaluation, synthesis, and characterization of nanoparticles (PAE AgO NPs) using UV\u2013visible, FTIR, XRD, SEM, FESEM\u2013EDX, and dynamic light scattering (DLS) with zeta potential. The study also assessed the anti\u2010inflammatory, antidiabetic, and antibacterial activities of the extracts and nanoparticles. GC\u2013MS analysis identified 30 distinct secondary metabolites. Among the tested solvents, the ethanolic crude extract demonstrated the highest antioxidant capacity, with the lowest IC<jats:sub>50<\/jats:sub> value compared to petroleum ether, chloroform, and aqueous extracts. Characterization of AgO NPs revealed a tetragonal crystalline structure with an average size of 13.66\u00a0nm. AgO NPs exhibited notable anti\u2010inflammatory and antidiabetic activities. Furthermore, ethanolic crude extracts (75\u2013300\u00a0\u00b5g\/mL) and AgO NPs (37.5\u2013150\u00a0\u00b5g\/mL) significantly inhibited the growth of <jats:italic>Klebsiella pneumoniae<\/jats:italic>, <jats:italic>Citrobacter<\/jats:italic> sp., <jats:italic>Salmonella typhi<\/jats:italic>, <jats:italic>Bacillus subtilis<\/jats:italic>, and <jats:italic>Enterococcus faecalis<\/jats:italic>. The antibacterial activity was quantified using minimum bactericidal concentrations (MBCs) and minimum inhibitory concentrations (MICs). Compared to crude extracts, the green\u2010synthesized AgO NPs from ethanolic extracts demonstrated superior antibacterial efficacy, with larger zones of inhibition and lower MIC and MBC values.<\/jats:p>","DOI":"10.1002\/cbdv.202403059","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T17:19:09Z","timestamp":1751217549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant and Metabolomic Profile of <i>Psychotria adenophylla<\/i>: Green Synthesis of AgO Nanoparticles With Anti\u2010Inflammatory, Antidiabetic, Antibacterial Activities"],"prefix":"10.1002","author":[{"given":"Debasish","family":"Dikshit","sequence":"first","affiliation":[{"name":"Department of Botany Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamir Sultan","family":"Lone","sequence":"additional","affiliation":[{"name":"Department of Botany Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Topi","family":"Karga","sequence":"additional","affiliation":[{"name":"Department of Botany Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-0044","authenticated-orcid":false,"given":"Mohd.","family":"Shahnawaz","sequence":"additional","affiliation":[{"name":"Department of Botany, Govt. 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