{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:10:27Z","timestamp":1778602227074,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The study examines the chemical composition and antimicrobial properties of petroleum ether and hydro\u2010methanolic extracts of\n                    <jats:italic>Achillea santolina<\/jats:italic>\n                    from Algeria. Chemical profiling was performed using high\u2010performance liquid chromatography with diode array detection for the hydro\u2010methanolic extract and gas chromatography\u2010mass spectrometry for the petroleum ether extract. Antibacterial and antifungal activities were evaluated using the disc diffusion method and broth dilution technique. Epicatechin (24.54\u00a0mg\/g extract), and camphor (19.18%) were identified as main compounds in the hydro\u2010methanolic and petroleum ether extracts, respectively. Both extracts showed significant antibacterial effects against extended\u2010spectrum beta\u2010lactamase\u2010producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    strains, with inhibition diameters ranging from 10 to 13\u00a0mm, and minimum inhibitory concentration (MIC) values between 0.78 and 3.5\u00a0mg\/mL. Anti\u2010fungal activity was also notable, particularly against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , with an inhibition diameter of 14\u00a0mm, and MIC values between 0.39 and 1.56\u00a0mg\/mL. The hydro\u2010methanolic extract showed up to 90% of growth inhibition against\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    . These findings suggest that\n                    <jats:italic>A. santolina<\/jats:italic>\n                    could serve as a promising source of antimicrobial compounds to combat resistant pathogens.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403064","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:41:21Z","timestamp":1734950481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemical Profiling by High\u2010Performance Liquid Chromatography With Diode Array Detection and Gas Chromatography\u2010Mass Spectrometry Analysis and Antimicrobial Potential of\n                    <i>Achillea santolina<\/i>\n                    Plant Extracts against Extended\u2010Spectrum Beta\u2010Lactamase\u2010producing\n                    <i>Escherichia coli<\/i>\n                    and Fungal Pathogens"],"prefix":"10.1002","volume":"22","author":[{"given":"Chahna","family":"Renda","sequence":"first","affiliation":[{"name":"Department of Biology Laboratory of Plant Biology and Environment \u201cMedicinal plants\u201d Axis Faculty of Sciences Badji Mokhtar \u2014 Annaba University, 12 P.O. Box, 23000 Annaba  Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadou","family":"Nina","sequence":"additional","affiliation":[{"name":"Department of Biology Laboratory of Plant Biology and Environment \u201cMedicinal plants\u201d Axis Faculty of Sciences Badji Mokhtar \u2014 Annaba University, 12 P.O. Box, 23000 Annaba  Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouzana","family":"Amina","sequence":"additional","affiliation":[{"name":"Department of Nature and Life Sciences, Laboratory of Interactions, Biodiversity, Ecosystems and Biotechnology, Faculty of Sciences University 20 August 1955  Skikda Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bougouizi","family":"Amina","sequence":"additional","affiliation":[{"name":"Department of Nature and Life Sciences, Laboratory of Interactions, Biodiversity, Ecosystems and Biotechnology, Faculty of Sciences University 20 August 1955  Skikda Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haouame","family":"Imane","sequence":"additional","affiliation":[{"name":"Department of Natural and Life Sciences Faculty of Sciences University of M'sila  M'sila Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebbas","family":"Khellaf","sequence":"additional","affiliation":[{"name":"Department of Natural and Life Sciences Faculty of Sciences University of M'sila  M'sila Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.115918"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1430564"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817176.ch2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(10)70218\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1400105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002170100416"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4419\u20104431.2004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.32406\/v7n2\/2024\/106\u2010126\/agrariacad"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(03)00149\u20101"},{"key":"e_1_2_9_13_1","first-page":"956","article-title":"Nouvelle Flore De l\u02bcAlg\u00e9rie et Des R\u00e9gions D\u00e9sertiques M\u00e9ridionales, Paris","volume":"2","author":"Quezel P.","year":"1963","journal-title":"Centre National De La Recherche Scientifique"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4172\/1948\u20105948.S8\u2010006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.48.273"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1274"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1303\/aez.2008.599"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2020.1723442"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201800075"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2001.9699674"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010018\u20109793\u20105"},{"key":"e_1_2_9_22_1","first-page":"56","article-title":"Chemical Composition and Antioxidant Activity of Essential Oil of Achillea Santolina","author":"Al\u2010Shuneigat J.","year":"2020","journal-title":"Indian Journal of Natural Scinces"},{"issue":"3","key":"e_1_2_9_23_1","first-page":"226","article-title":"Comparative Study of the Essential Oils and Extracts of Achillea fragrantissima (Forssk.) 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