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The insecticidal effects and antifungal activities of these compounds against plant pathogenic fungi were evaluated. Bioactivity assessments revealed that compound\n                    <jats:bold>5i<\/jats:bold>\n                    exhibited the highest larvicidal activity against\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , with a mortality rate of 96% after 24\u00a0h of treatment. Compounds\n                    <jats:bold>5i<\/jats:bold>\n                    ,\n                    <jats:bold>5e<\/jats:bold>\n                    , and\n                    <jats:bold>5a<\/jats:bold>\n                    displayed the strongest antifungal activity against\n                    <jats:italic>Colletotrichum musae<\/jats:italic>\n                    , with median effective concentration values of 0.42, 3.44, and 3.67\u00a0mg\/L, respectively, outperforming the commercial fungicide bromothalonil (9.31\u00a0mg\/L) and comparable to chlorothalonil (0.74\u00a0mg\/L). Structure\u2010activity relationship analysis indicated that the presence of a chlorine atom at the 4\u2010position of the phenyl ring was critical for the bioactivity of the compounds. Docking results indicated that compound\n                    <jats:bold>5i<\/jats:bold>\n                    exhibited the strongest binding affinity for succinate dehydrogenase, providing insights for further mechanistic studies. These findings suggest the significant potential of these compounds as lead candidates for in\u2010depth research and development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403118","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T06:28:08Z","timestamp":1739255288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Design, Synthesis, and Evaluation of 7\u2010Vinylcoumarin Derivatives as Agrochemicals: Biological Activities and Molecular Docking Insights"],"prefix":"10.1002","volume":"22","author":[{"given":"Jianwen","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Tropical Agriculture and Forestry Hainan University  Danzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry Hainan University  Danzhou 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