{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:45:57Z","timestamp":1773013557705,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373747"],"award-info":[{"award-number":["82373747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273803"],"award-info":[{"award-number":["82273803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173695"],"award-info":[{"award-number":["82173695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n An unusual C\n 15<\/jats:sub>\n nor<\/jats:italic>\n \u2010halimane\u2010type diterpenoid, norcrohalane A (\n 1<\/jats:bold>\n ), a new\n nor<\/jats:italic>\n \u2010lasserane\u2010type sesquiterpenoid, norcrolasane A (\n 2<\/jats:bold>\n ), along with four known compounds (\n 3\u20136<\/jats:bold>\n ) were isolated from the roots of\n Croton crassifolius<\/jats:italic>\n . Compound\n 1<\/jats:bold>\n represents the first example of a C\n 15<\/jats:sub>\n nor<\/jats:italic>\n \u2010halimane\u2010type diterpenoid, which features a rare 6\/6\/6 tricyclic ring system, and the A ring is aromatic. Compound\n 2<\/jats:bold>\n is a rare\n nor<\/jats:italic>\n \u2010lasserane\u2010type sesquiterpenoid. Their structures and absolute configurations were established by a combination of mass spectrometry, nuclear magnetic resonance, electronic circular dichroism calculation, and single\u2010crystal X\u2010ray diffraction analyses. The anti\u2010neuroinflammatory activities of\n 1\u20136<\/jats:bold>\n were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide\u2010induced BV2 cells, and compounds\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n showed moderate inhibition on NO production with IC\n 50<\/jats:sub>\n values of 26.82 \u00b1\u00a00.61 and 17.35 \u00b1\u00a00.78 \u00b5M, respectively.\n <\/jats:p>","DOI":"10.1002\/cbdv.202403123","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:34:43Z","timestamp":1734957283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Norcrohalane A, an Unusual C\n 15<\/sub>\n nor<\/i>\n \u2010Halimane\u2010Type Diterpenoid from\n Croton crassifolius<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Qing","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Xuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian\u2010Yi","family":"Situ","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Lin","family":"Ou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can\u2010Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangdong Clinical Translational Center for Targeted Drug School of Medicine Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"},{"name":"Department of Pharmacology Guangdong Clinical Translational Center for Targeted Drug School of Medicine Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1196-7850","authenticated-orcid":false,"given":"Guo\u2010Cai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2015.12.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2012.694872"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117352"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-13-12882"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00634"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300636k"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00425"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.733350"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1652290"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-022-01630-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1731739"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.01.055"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1601193"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2018.1465413"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202101028"},{"key":"e_1_2_9_17_1","first-page":"803","article-title":"Pyran\u20102\u2010one Derivatives From the Roots of Croton Crassifolius","volume":"11","author":"Huang W. 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