{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:45:25Z","timestamp":1783565125258,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three new pyridine derivatives, irpelactedines A\u2013C (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ), and a new furan derivative, irpelactedine D (\n                    <jats:bold>5<\/jats:bold>\n                    ), along with two structurally related known compounds, irpexidine A (\n                    <jats:bold>4<\/jats:bold>\n                    ) and 5\u2010carboxy\u20102\u2010furanpropanoic acid (\n                    <jats:bold>6<\/jats:bold>\n                    ), were isolated from the medicinal fungus\n                    <jats:italic>Irpex lacteus<\/jats:italic>\n                    SY1002. Their structures were elucidated through nuclear magnetic resonance and mass spectral analyses, combined with density functional theory calculations of electronic circular dichroism data. Evaluation of angiotensin\u2010converting enzyme (ACE) inhibitory activity revealed that compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    displayed moderate inhibition, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 31.49 \u00b1 3.41 and 80.96 \u00b1 6.93\u00a0\u00b5g\/mL, respectively. Molecular docking suggested that compound\n                    <jats:bold>1<\/jats:bold>\n                    is bound to the active site of ACE, leading to a reduction in its activity. Furthermore, cytotoxicity and antimicrobial activity tests revealed the low toxicity of these compounds. This is the first report on the ACE inhibitory activity of this class of pyridine derivatives, providing valuable insights into exploring the medicinal potential of\n                    <jats:italic>I. lacteus<\/jats:italic>\n                    and offering a structural template for developing new ACE inhibitors. Future efforts will focus on optimizing their structure and conducting in vivo testing to assess their therapeutic potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403124","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T12:29:49Z","timestamp":1737808189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pyridine Derivatives and Furan Derivatives Identified From the Medicinal Mushroom\n                    <i>Irpex lacteus<\/i>\n                    SY1002"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-0548","authenticated-orcid":false,"given":"Guihong","family":"Yu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Shandong Province Key Laboratory of Applied Mycology, and Qingdao International Center on Microbes Utilizing Biogas Qingdao Agricultural University, Qingdao Shandong 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