{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:38:10Z","timestamp":1788946690305,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gray mold disease is caused by\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    , which could severely reduce the production yield and quality of tomatoes. To explore more potential fungicides with new scaffolds for controlling gray mold disease, 10 aldehydes\u2010thiourea derivatives were designed, synthesized, and assayed for inhibitory activity against three plant pathogenic fungi. The preliminary antifungal assay suggested that some title derivatives showed moderate to good antifungal activity against\n                    <jats:italic>B. cinerea<\/jats:italic>\n                    . In particular, compound\n                    <jats:bold>9<\/jats:bold>\n                    presented excellent in vitro antifungal activity against\n                    <jats:italic>B. cinerea<\/jats:italic>\n                    (half maximal effective concentration [EC\n                    <jats:sub>50<\/jats:sub>\n                    ] = 0.70\u00a0mg\/L), which was superior to boscalid (EC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.41\u00a0mg\/L). In vivo antifungal assay indicated\n                    <jats:bold>9<\/jats:bold>\n                    displayed good protective effects on tomato leaves infected by\n                    <jats:italic>B. cinerea<\/jats:italic>\n                    . A preliminary mechanism study displayed that\n                    <jats:bold>9<\/jats:bold>\n                    could damage the surface morphology, increase the cell membrane permeability, and lead to the increase of reactive oxygen species level. Enzyme inhibition assay illustrated that\n                    <jats:bold>9<\/jats:bold>\n                    could be a potential laccase inhibitor. The above bioassay results and mechanism investigation demonstrated that aldehydes\u2010thiourea derivatives could be promising fungicides for further controlling postharvest gray mold disease, which would be potential candidates for fungicidal compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403131","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:21:03Z","timestamp":1737436863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis and Antifungal Activity of Aldehydes\u2010Thiourea Derivatives as Promising Antifungal Agents Against Postharvest Gray Mold Disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-5107","authenticated-orcid":false,"given":"Zi Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Academy of Science and Technology Chuxiong Normal University  Chuxiong China"},{"name":"College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Science and Technology Chuxiong Normal University  Chuxiong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Resources Environment and Chemistry Chuxiong Normal University  Chuxiong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00449-20"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00214"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100521"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43897-021-00004-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.934857"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.756329"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.12.065"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800275"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2014.10.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16010001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c04064"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.11.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.074"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2016.07.075"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.805755"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.126904"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.03.047"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1067-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.112"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.05.056"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2017.1370589"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8417"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.126885"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.52568\/000599"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129574"},{"key":"e_1_2_9_28_1","article-title":"Computational and Experimental Insights Into Pharmacological Potential: Synthesis, In Vitro Evaluation, and Molecular Docking Analysis of Bioactive Urea and Thiourea Derivatives","author":"Babu D.","year":"2024","journal-title":"Microbial Pathogenesis"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202301998"},{"issue":"8","key":"e_1_2_9_30_1","article-title":"Bis(azolyl)Pyridine\u20102,6\u2010dicarboxamide Derivatives: Synthesis","volume":"12","author":"Kumar M. 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