{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:06:28Z","timestamp":1782990388269,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    One previously undescribed C\n                    <jats:sub>22<\/jats:sub>\n                    \u2010diterpenoid alkaloid (DHS\u2010DA\u20101) was isolated from\n                    <jats:italic>Dendrobium huoshanense<\/jats:italic>\n                    C. Z. Tang et S. J. Cheng. The structure of the new alkaloid was elucidated using extensive spectroscopic analyses and NMR calculations. Griess reaction results showed that the new compound could reduce the creation of nitric oxide (NO) in lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 macrophages, and the ELISA experiments suggested that DHS\u2010DA\u20101 could efficaciously decrease LPS\u2010induced inflammation by inhibiting tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106) expressions. In addition, DHS\u2010DA\u20101 could effectively inhibit the survival and proliferation of AGS cells and promote their apoptosis in a concentration\u2010dependent manner. The stability and feasibility of binding the DHS\u2010DA\u20101 to the target protein are further verified by molecular docking and molecular dynamics simulation validation. In addition, DHS\u2010DA\u20101 exhibits favorable ADMET properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403181","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T23:00:02Z","timestamp":1744671602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["One Novel C\n                    <sub>22<\/sub>\n                    \u2010Diterpenoid Alkaloid From\n                    <i>Dendrobium huoshanense<\/i>\n                    and Its Primary In Vitro Bioactive Evaluation As Well As the Molecular Dynamics Simulations"],"prefix":"10.1002","volume":"22","author":[{"given":"Sheng\u2010Xiang","family":"Wei","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Traditional Chinese Medicine  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory for Quality Evaluation and Improvement of Traditional Chinese Medicine  Lu'an Anhui 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