{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:29:59Z","timestamp":1792308599846,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Plants have been used in traditional medicine for centuries, providing a variety of biological benefits, including antioxidant and anticancer activity, due to their phytochemical composition. This study investigates the biological activity and chemical composition of <jats:italic>Centaurea saligna<\/jats:italic>, <jats:italic>Centaurea bingoelensis<\/jats:italic>, and <jats:italic>Centaurea pyrrhoblephara<\/jats:italic>, key species of the Asteraceae family, to explore their potential for developing novel therapeutic strategies. Methanol extracts of these species were analyzed for their inhibitory effects on \u03b1\u2010glucosidase, AChE, and BuChE enzymes. Their lipophilic components were characterized using GC\u2010MS, phenolic profiles via Orbitrap HPLC\u2010HRMS, and total phenol and flavonoid contents were quantified using established methods. Antioxidant activities were evaluated through DPPH, ABTS, ferric ion reducing, and ferrous ion chelating assays. Cytotoxic effects were assessed on HT\u201029 colorectal and A549 lung cancer cells through WST\u20101 analysis, determining IC<jats:sub>50<\/jats:sub> values. In addition, anticancer activity findings were supported by colony survival and cell migration analyses. Apoptotic activity of the applied treatments was observed by AO\/EB dual staining, caspase\u20103 ELISA, and Western blot analysis. Notably, the extracts significantly induced apoptosis in HT\u201029 cells, evidenced by increased apoptotic indices, cleaved PARP, and p53 expression, with <jats:italic>C. pyrrhoblephara<\/jats:italic> exhibiting the strongest proapoptotic activity.<\/jats:p>","DOI":"10.1002\/cbdv.202403185","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T18:38:14Z","timestamp":1743705494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deciphering the Anticancer, Antioxidant, Enzyme Inhibition Potentials, and Phytochemical Compositions of Some Endemic <i>Centaurea<\/i> Species"],"prefix":"10.1002","author":[{"given":"Mehmet Kadir","family":"Erdogan","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Arts and Sciences Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Vocational School of Health Services Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Toy","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Arts and Sciences Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Halil","family":"Gecibesler","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Faculty of Health Science Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfi","family":"Behcet","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Arts and Sciences Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahinur","family":"Kirici","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Arts and Sciences Bingol University  Bingol T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"121","volume":"43","author":"Bona M.","year":"2013","journal-title":"Journal of Faculty of Pharmacy of Istanbul University"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4314\/tjpr.v13i4.19","article-title":"Fatty Acid Composition of the Aerial Parts of some Centaurea Species in Elazig, Turkey","volume":"13","author":"Erdogan T.","year":"2014","journal-title":"Tropical Journal of Pharmaceutical Research"},{"issue":"3","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/molecules21030257","article-title":"Potential Use of Turkish Medicinal Plants in the Treatment of Various Diseases","volume":"21","author":"Ozkan G.","year":"2016","journal-title":"Molecules"},{"issue":"6","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.apjtm.2016.04.016","article-title":"Chemical Constituents, Cytotoxic, Antifungal and Antimicrobial Properties of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) 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