{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:56:44Z","timestamp":1791982604658,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100022957","name":"Double Thousand Plan of Jiangxi Province","doi-asserted-by":"publisher","award":["jxsq2023102015"],"award-info":[{"award-number":["jxsq2023102015"]}],"id":[{"id":"10.13039\/100022957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four unreported pyridine alkaloids, curviflorines A\u2013D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ), two undescribed iridoids, curviridoids A and B (\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    ), and one known iridoid glycoside (\n                    <jats:bold>7<\/jats:bold>\n                    ), were isolated from the twigs and leaves of\n                    <jats:italic>Phlogacanthus curviflorus<\/jats:italic>\n                    . The structures of these compounds were established by detailed interpretation of MS and NMR data, with the absolute configurations being assigned via comparison of experimental and calculated electronic circular dichroism spectra. Notably, it is the first report of alkaloidal constituents (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) from the genus\n                    <jats:italic>Phlogacanthus<\/jats:italic>\n                    . Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    did not show obvious inhibitory activities against \u03b1\u2010glucosidase and NO production (in RAW264.7 macrophages), nor did they exhibit anti\u2010oxidant activity and cytotoxicity towards MDA\u2010MB231, A549 and HeLa cancer cell lines. Nevertheless, alkaloids\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    did exert a significant suppressing effect on TGF\u2010\u03b21\u2010induced upregulation of the fibrotic marker protein fibronectin in HK\u20102 cells, indicating their antifibrotic potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403234","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:24:17Z","timestamp":1735280657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alkaloids and Iridoids From\n                    <i>Phlogacanthus curviflorus<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Qian","family":"Wu","sequence":"first","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Fen","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010Hao","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Cheng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5959-6473","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"The World Flora Online https:\/\/www.worldfloraonline.org\/taxon\/wfo\u20104000029277."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0497999"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200800274"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)81439-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329-6836.1000229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60464-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)83117-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-023-00731-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2021.1913125"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.08.013"},{"key":"e_1_2_9_12_1","first-page":"77","article-title":"Extraction of Phenolic Compounds From Mango Peels","volume":"42","author":"Palmeira S. 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