{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:40:52Z","timestamp":1792132852047,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Rheum ribes<\/jats:italic> L. (rhubarb) is a valuable plant that is consumed raw and cooked and contains important secondary metabolites. This study aimed to investigate the chemical profile and biological activities of different extracts (ethyl acetate, methanol, and water) of aerial parts and roots of <jats:italic>R. ribes<\/jats:italic>. Antioxidant and enzyme inhibitory properties were examined for biological activities. The antioxidant properties were examined by various chemical tests, including free radical scavenging (2,2'\u2010azino\u2010bis[3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid] and 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl), reducing the ability (cupric reducing antioxidant capacity and ferric reducing antioxidant power), metal chelation and phosphomolybdenum. The inhibitory effect of the extracts was investigated against cholinesterase, amylase, glucosidase, and tyrosinase. In addition, the total amounts of phenolics and flavonoids in each extract were detected by spectrophotometric methods. The chemical compounds of the extracts were identified using liquid chromatography\u2010electrospray ionization tandem mass spectrometry technique. The extraction solvents changed the total phenolics and flavonoids content, and the highest total phenolics contents of both parts were found in the methanol extract (root: 140.97\u00a0mg gallic acid equivalent (GAE)\/g; aerial parts: 74.56\u00a0mg GAE\/g). In the chemical profile, it was found that hesperidin is the main component in the extracts of the aerial part (613.48\u201312194.83\u00a0\u00b5g\/g of extract), while in the root extracts, the dominant components are catechin (799.11\u20133230.44\u00a0\u00b5g\/g extract) and gallic acid was (184.03\u2013960.58\u00a0\u00b5g\/g extract). The methanol extract of the roots provided the best radical scavenging and reducing ability. In contrast, the methanol extract of the aerial parts had the greatest metal chelating ability (62.05\u00a0mg ethylenediaminetetraacetate equivalent\/g). The best acetylcholinesterase and butrylcholinesterase abilities were determined in the methanol extracts of both parts. However, the ethyl acetate extracts were the most active on amylase. Our results suggest that <jats:italic>R. ribes<\/jats:italic> can be considered a valuable source of bioactive compounds for developing health\u2010promoting applications.<\/jats:p>","DOI":"10.1002\/cbdv.202403240","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:07:34Z","timestamp":1741590454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of <i>Rheum ribes<\/i> Parts"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"G\u00f6khan","family":"Zengin","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-506X","authenticated-orcid":false,"given":"Emine","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-0054","authenticated-orcid":false,"given":"Kubilay","family":"Toyran","sequence":"additional","affiliation":[{"name":"Eldivan Vocational School of Health Services \u00c7ank\u0131r\u0131 Karatekin University  Cankiri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-4969","authenticated-orcid":false,"given":"Atilla","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-2986","authenticated-orcid":false,"given":"G\u00f6zde","family":"Koygun","sequence":"additional","affiliation":[{"name":"Hexagraphene Nanotechnology Industry and Trade Inc. Dallata Consulting Group  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.69.197"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Chemistry and Pharmacology Of Rhubarb (Rheum species)\u2014A Review","volume":"60","author":"Agarwal S. K.","year":"2001","journal-title":"Journal of Scientific & Industrial Research"},{"key":"e_1_2_7_4_1","volume-title":"Flora of Turkey and East Aegean Islands","author":"Davis P. H.","year":"1967"},{"key":"e_1_2_7_5_1","first-page":"10","article-title":"Synthesis of 1, 2, 3, 4, 5, 6, 7, 8\u2010Octahydro\u20109\u2010Ethoxy\u201010\u2010Hydroxy\u20101\u2010Anthracenone [OEHA]","volume":"16","author":"Shockravi A.","year":"1997","journal-title":"Iranian Journal Of Chemistry & Chemical Engineering\u2010International English Edition"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209409082966"},{"key":"e_1_2_7_7_1","unstructured":"E.TuzlaciandA.Mericli \u201cSome Studies on Isgin (Rheum ribes) and Its Distribution in Turkey \u201d inProceedings of the IX Symposium on Plant Drugs No. 641 ed.K. C. H.Baser(Eskisehir:Publication of Anadolu University 1992) 336\u2013341."},{"key":"e_1_2_7_8_1","first-page":"319","article-title":"Rheum ribes L.","volume":"1","author":"Baytop T.","year":"1999","journal-title":"Therapy with Medicinal Plants in Turkey"},{"key":"e_1_2_7_9_1","first-page":"90","article-title":"Investigations Into the Anti\u2010Ulcer Activity of Rheum ribes Linn Leaves Extracts","volume":"2","author":"Sindhu R. K.","year":"2010","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(88)80218-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00283-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/J157v06n02_03"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200902748478"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2010.539619"},{"key":"e_1_2_7_15_1","first-page":"573","article-title":"Efficacy of Hydroalcoholic Extract of Rheum ribes L. in Treatment of Major Depressive Disorder","volume":"3","author":"Sayyah M.","year":"2009","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.05.050"},{"key":"e_1_2_7_17_1","first-page":"392","article-title":"Renoprotective Effect of Hydroalcoholic Extract of Rheum ribes Root in Diabetic Female Rats","volume":"4","author":"Hamzeh S.","year":"2014","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_7_18_1","first-page":"1197","article-title":"Effect of Rheum ribes Hydro\u2010Alcoholic Extract on Memory Impairments in Rat Model of Alzheimer's Disease","volume":"14","author":"Zahedi M.","year":"2015","journal-title":"Iranian Journal of Pharmaceutical Research: IJPR"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.12.054"},{"key":"e_1_2_7_20_1","first-page":"3047","article-title":"Antioxidant Activity of Different Parts of Isgin (Rheum ribes L.)","volume":"19","author":"Oktay M.","year":"2007","journal-title":"Asian Journal of Chemistry"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1977.28.1.49"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmy003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2017.03.005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111666"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2019.10.025"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ay41125g"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.116836"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1560294"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/1158\/4\/042068"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-020-0057-8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.05.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030528"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11010023"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.110683"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26862"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114068"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14994"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2020.1745917"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02258"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081618"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13031503"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jarmap.2019.100224"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109643"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113616"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4019"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540701230529"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111527"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113477"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126277"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/9151180"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2478\/auoc-2019-0008"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.09.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1556\/AAlim.42.2013.4.1"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.26650\/IstanbulJPharm.2019.18012"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2006000200021"},{"key":"e_1_2_7_56_1","first-page":"177","article-title":"Natural Products as A Potential Enzyme Inhibitors From Medicinal Plants","volume":"165","author":"Rauf A.","year":"2017","journal-title":"Enzyme Inhibitors and Activators"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.06.029"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.12.047"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126930"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T18:18:01Z","timestamp":1753294681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202403240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/cbdv.202403240"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202403240","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"2024-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202403240"}}