{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:57:10Z","timestamp":1755226630696,"version":"3.43.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chronic inflammation can lead to various diseases, including gastric ulcers, highlighting the need for effective therapeutic strategies. The traditional use of <jats:italic>Chamaerops humilis<\/jats:italic> in Moroccan folk medicine for treating gastrointestinal disorders underscores its potential as a valuable natural remedy. This study rigorously evaluates the anti\u2010inflammatory and gastroprotective effects of the aqueous extract of <jats:italic>C. humilis<\/jats:italic> (AECH) through a series of well\u2010established animal models, including carrageenan\u2010induced paw edema, xylene\u2010induced ear edema, and ethanol\/hydrochloric acid (EtOH\/HCL)\u2010induced gastric ulcers. The results reveal that AECH significantly reduces inflammation and ulcer severity in a dose\u2010dependent manner, demonstrating potent efficacy in decreasing paw and ear edema while markedly mitigating ulceration induced by EtOH\/HCL exposure. Notably, AECH achieved up to 100% inhibition of ulcer lesions at higher doses. These findings not only validate the traditional applications of <jats:italic>C. humilis<\/jats:italic> but also highlight its promising role as a natural therapeutic agent for managing inflammatory conditions and gastric ulcers.<\/jats:p>","DOI":"10.1002\/cbdv.202403241","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:23:26Z","timestamp":1742397806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010inflammatory and Gastroprotective Effects of the <i>Chamaerops humilis<\/i> L. (DOUM) Fruit Aqueous Extract in Experimental Models of Edema and Gastric Ulcer"],"prefix":"10.1002","author":[{"given":"Yasmina","family":"Jaouhari","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Kabdy","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouijdane","family":"El hatimy","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar","family":"Azraida","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baslam","family":"Abdelmounaim","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfattah","family":"Aitbaba","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Semlalia Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Cadi Ayyad University  Marrakech Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laadraoui","family":"Jawad","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Genetic Molecular and Biotechnology, Faculty of Sciences, A\u00efn Chock, Hassan II University  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassine","family":"Chait","sequence":"additional","affiliation":[{"name":"Agadir Souss Massa University Hospital, Faculty of Medicine and Pharmacy, Ibn Zohr University  Agadir Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachida","family":"Aboufatima","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Engineering, Faculty of Sciences and Technology, Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad","family":"Moubtakir","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences 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