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It was functionalized with citric acid to prevent clumping and maintain stability. To increase the interaction efficiency between the delivery system and the drug, leucine\u2013glycine dipeptide and an amphiphilic polymer, Pluronic F127, were attached to the nanoparticle. Characterization studies were carried out with XRD, ICP\u2013MS, vibrating sample magnetometer (VSM), TEM, and zeta potential to elucidate the structure of this carrier system. After docetaxel was bound to the synthesized carrier, its therapeutic effect was measured by spectrophotometric and flow cytometric methods (3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide [MTT], reactive oxygen species [ROS], and apoptosis). Docetaxel\u2010bound nanoparticles significantly reduced the viability of the tumor cell compared to the healthy cell in a dose\u2010dependent manner, especially at 24 (50.14\u00a0\u00b1\u00a013.25 to 22.32\u00a0\u00b1\u00a05.51 at 100\u00a0\u00b5g\/mL)\u00a0h and 48 (41.46\u00a0\u00b1\u00a02.22 to 18.80\u00a0\u00b1\u00a02.81 at 100\u00a0\u00b5g\/mL)\u00a0h. The rate of apoptosis and ROS in the negative sample increased from 2.7% to 15.4% and from 9.6% to 74.7%, respectively, as a result of treatment with 15\u00a0\u00b5g\/mL \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>\/C\/LG\/F127\/Dotx. Thus, it can be said that the synthesized carrier system is a suitable candidate for the improvement of docetaxel transport.<\/jats:p>","DOI":"10.1002\/cbdv.202403245","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:09:26Z","timestamp":1741763366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Docetaxel\u2010Loaded, Dipeptide\u2010Functionalized \u03b3\u2010Fe<sub>2<\/sub>O<sub>3<\/sub> Magnetic Nanoparticles: Synthesis, Characterization, and Targeting to Prostate Cancer"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-7086","authenticated-orcid":false,"given":"Muhammed","family":"Gungoren","sequence":"first","affiliation":[{"name":"Health Services Vocational High School, Department of Medical Marketing and Promotion Mardin Artuklu University  Mardin 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