{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:05:19Z","timestamp":1792065919374,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cariniana rubra<\/jats:italic>\n                    , native to the Brazilian Cerrado and the Amazon\u2010Cerrado ecotone, is traditionally used in folk medicine but remains underexplored. This study optimized extraction yield and bioactive compound content using ultrasound\u2010assisted extraction (UAE) and Soxhlet extraction. A central composite rotational design (CCRD) assessed ethanol concentration and extraction time, with response surface modeling (RSM) determining optimal conditions. UAE yielded 49.60% (50% ethanol, 132\u00a0min) and Soxhlet 25.25% (78% ethanol, 300\u00a0min). Maximum phenolic compound contents were 382.62\u00a0mg GAE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    (UAE; 48\u00a0min) and 385.95\u00a0mg GAE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    (Soxhlet; 480\u00a0min). Flavonoid contents were 137.83\u00a0mg QE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    (UAE; 90\u00a0min) and 73.66\u00a0mg QE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    (Soxhlet; 120\u00a0min). Antioxidant activity was confirmed by DPPH\u2022, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 37.73\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (UAE) and 36.20\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (Soxhlet), surpassing Trolox (23.64\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and equivalent to Trolox in ABTS assays (53.67 and 38.67\u00a0\u00b5M Trolox\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and FRAP (453.44 and 558.44\u00a0\u00b5M Fe\n                    <jats:sup>2+<\/jats:sup>\n                    \u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). FT\u2010IR analysis confirmed phenolic compound indicators, while LC\u2013DAD identified epicatechin, rutin, and myricetin. These optimized methods produced extracts with high antioxidant activity, suggesting potential for further applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403256","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:19:44Z","timestamp":1752779984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficient Extraction of Phenolic Compounds From\n                    <i>Cariniana rubra<\/i>\n                    Gardener Ex Miers From the Legal Amazon: Ultrasound\u2010Assisted Optimization, Chemical Characterization, and Antioxidant Potential"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-2297","authenticated-orcid":false,"given":"Aline Biggi","family":"Maciel","sequence":"first","affiliation":[{"name":"Graduate Program in Biodiversity and Biotechnology\u2014BIONORTE Federal University of Tocantins, Palmas Campus  Palmas Tocantins Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elis Ramos","family":"de Queiroz J\u00e1come","sequence":"additional","affiliation":[{"name":"Laboratory of Teaching and Research in Natural Products and Biomass Federal University of Tocantins  Palmas Tocantins Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00edsa","family":"Andrade da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Teaching and Research in Natural Products and Biomass Federal University of Tocantins  Palmas Tocantins Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-8961","authenticated-orcid":false,"given":"Rachel de Moura Nunes","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Chemistry Laboratory Federal University of Tocantins  Palmas Tocantins Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-0056","authenticated-orcid":false,"given":"Claudia Andrea Lima","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Center For Studies in Natural Resources State University of Mato Grosso Do Sul  Dourados Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-308X","authenticated-orcid":false,"given":"Elisandra","family":"Scapin","sequence":"additional","affiliation":[{"name":"Graduate Program in Biodiversity and Biotechnology\u2014BIONORTE Federal University of Tocantins, Palmas Campus  Palmas Tocantins Brazil"},{"name":"Laboratory of Teaching and Research in Natural Products and Biomass Federal University of Tocantins  Palmas Tocantins Brazil"},{"name":"Chemistry Laboratory Federal University of Tocantins  Palmas Tocantins Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102-33062019abb0152"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.flora.2023.152366"},{"key":"e_1_2_9_4_1","volume-title":"Plantas Medicinais de Mato Grosso: A Farmacop\u00e9ia Popular Dos Raizeiros","author":"De M. 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