{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:57:16Z","timestamp":1773280636561,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parasitic diseases such as trypanosomiasis and leishmaniasis pose significant health challenges in Africa. The Senegalese Pharmacopoeia, known for its many medicinal plants with anti\u2010infectious properties, can be a source of antiparasitic natural products. This study aimed to evaluate the in vitro antiparasitic activities of 33 methanolic extracts from 24 ethnopharmacologically selected plants against\n                    <jats:italic>Trypanosoma brucei brucei<\/jats:italic>\n                    (Tbb) and\n                    <jats:italic>Leishmania mexicana mexicana<\/jats:italic>\n                    (Lmm), as well as their cytotoxic activities on WI\u201038 cells. The most promising plant species were\n                    <jats:italic>Balanites aegyptiaca<\/jats:italic>\n                    ,\n                    <jats:italic>Eucalyptus camaldulensis<\/jats:italic>\n                    ,\n                    <jats:italic>Vachellia nilotica<\/jats:italic>\n                    and four Combretaceae species. In a second step, antitrypanosomal and antileishmanial compounds were isolated by preparative high\u2010performance liquid chromatography from one of the most active plant extracts,\n                    <jats:italic>Terminalia avicennioides<\/jats:italic>\n                    leaves. Four ellagic acid derivatives were identified by nuclear magnetic resonance (1D &amp; 2D) and high\u2010resolution electrospray ionization\u2010tandem mass spectrometry (HR\u2010ESI\u2010MS\/MS) as 3,4,3\u2010tri\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010methylellagic acid (\n                    <jats:bold>2<\/jats:bold>\n                    ), 3,4,5\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010trimethyl\u20103',4'\u2010\n                    <jats:italic>O<\/jats:italic>\n                    ,\n                    <jats:italic>O<\/jats:italic>\n                    \u2010methylideneflavellagic acid (\n                    <jats:bold>3<\/jats:bold>\n                    ), hexamethylcoruleoellagic acid (\n                    <jats:bold>4<\/jats:bold>\n                    ) and pentamethylflavellagic acid (\n                    <jats:bold>5<\/jats:bold>\n                    ). In addition, HR\u2010ESI\u2010MS\/MS\u2010based dereplication analysis was performed to putatively identify compounds in active cyclohexane and dichloromethane sub\u2010extracts. Pentamethylflavellagic acid (\n                    <jats:bold>5<\/jats:bold>\n                    ) showed the most promising activity against Tbb (half\u2010maximal inhibitory concentration = 6.20 \u00b5M). This is the first time that these compounds have been isolated from\n                    <jats:italic>T. avicennioides<\/jats:italic>\n                    and evaluated for their antitrypanosomal and antileishmanial activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403320","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T11:10:31Z","timestamp":1737112231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiparasitic Activities of Plants From the Traditional Senegalese Pharmacopoeia: Isolation of Antitrypanosomal and Antileishmanial Ellagic Acid Derivatives From\n                    <i>Terminalia Avicennioides<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Abda","family":"Ba","sequence":"first","affiliation":[{"name":"Joint Research Unit 1158 BioEcoAgro Univ. Lille, Junia, INRAE, Univ. Li\u00e8ge, UPJV, Univ. Artois, ULCO  Lille France"},{"name":"Laboratoire de Chimie Organique et Th\u00e9rapeutique, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie de l'Universit\u00e9 Cheikh Anta Diop de Dakar  Dakar\u2010Fann Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Roumy","sequence":"additional","affiliation":[{"name":"Joint Research Unit 1158 BioEcoAgro Univ. Lille, Junia, INRAE, Univ. Li\u00e8ge, UPJV, Univ. Artois, ULCO  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristelle","family":"Hughes","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Group, Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Samaillie","sequence":"additional","affiliation":[{"name":"Joint Research Unit 1158 BioEcoAgro Univ. Lille, Junia, INRAE, Univ. Li\u00e8ge, UPJV, Univ. Artois, ULCO  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Bourlet","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Group, Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Hennebelle","sequence":"additional","affiliation":[{"name":"Joint Research Unit 1158 BioEcoAgro Univ. Lille, Junia, INRAE, Univ. Li\u00e8ge, UPJV, Univ. Artois, ULCO  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samba Fama","family":"Ndoye","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Organique et Th\u00e9rapeutique, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie de l'Universit\u00e9 Cheikh Anta Diop de Dakar  Dakar\u2010Fann Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010France","family":"Herent","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Group, Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle","family":"Quetin\u2010Leclercq","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Group, Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matar","family":"Seck","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Organique et Th\u00e9rapeutique, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie de l'Universit\u00e9 Cheikh Anta Diop de Dakar  Dakar\u2010Fann Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-5530","authenticated-orcid":false,"given":"C\u00e9line","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Joint Research Unit 1158 BioEcoAgro Univ. 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