{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:41:08Z","timestamp":1777592468048,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This research explores the medicinal potential of curcuminoids (CMNs) from turmeric and silymarin (SIL) from milk thistle for treating liver diseases. The study examines these compounds\u2019 individual and synergistic effects on liver dysfunction patients, focusing on their antioxidant, antimicrobial, and anticancer properties. A 4\u2010week clinical trial involving 15 participants diagnosed with nonalcoholic fatty liver disease (NAFLD) was conducted to evaluate the therapeutic benefits of these compounds. Participants were chosen based on specific health criteria, enhancing the research's real\u2010world applicability and instilling confidence in the practicality of the findings. Results indicated considerable antioxidant properties, antimicrobial effectiveness against pathogens like <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>, and anticancer potential against liver and colorectal cancers. Significant improvements in liver enzyme indicators and serum lipid levels were observed. These findings suggest that CMNs and SIL, particularly in combination, may serve as effective natural treatments for liver dysfunction, offering a promising alternative for enhancing liver health in affected individuals.<\/jats:p>","DOI":"10.1002\/cbdv.202403340","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T20:58:41Z","timestamp":1749848321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Effects of Curcuminoids and Silymarin, Individually and in Combination, in Patients With Hepatic Impairment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-7811","authenticated-orcid":false,"given":"Eman M.","family":"Elgendy","sequence":"first","affiliation":[{"name":"Department of Home Economy, Faculty of Specific Education Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid A.","family":"El Sherbiny","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal G.","family":"Sedki","sequence":"additional","affiliation":[{"name":"Department of Home Economy, Faculty of Specific Education Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba H.","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of Home Economy, Faculty of Specific Education Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114588"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.30596\/bf.v8i1.11478"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5958\/2249\u20107137.2021.02653.7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.ctppc.2023.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2023.2179454"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13137809"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c04205"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4469"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116034"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13030330"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1990"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy12030729"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2069854"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.143966"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092264"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15174"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.020"},{"key":"e_1_2_11_19_1","first-page":"285","article-title":"Hepatoprotective Medicinal Plants' Traditional Knowledge to Scientific Evidence","volume":"10","author":"Benny N. 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