{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:17:07Z","timestamp":1784542627174,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Based on the high expression of folic acid (FA) receptors in triple\u2010negative breast cancer cells, we encapsulated licochalcone A (LCA) in FA\u2010modified polyethylene glycol\u2010poly(lactic\u2010co\u2010glycolic) acid nanoparticles (NPs) for enhanced targeting and antitumor activity. In vitro experiments on 4T1 cells showed that NPs with FA modification exhibited excellent performance, including inhibition of cell proliferation, reduction of 50% inhibitory concentration values of LCA, and activation of reactive oxygen species production, thereby inhibiting cell proliferation. This drug delivery system promotes drug uptake by tumor cells and significantly improves drug delivery efficiency. Regarding relevant in vivo experiments in tumor\u2010bearing mice, we further demonstrated that NPs with FA modification have significant tumor\u2010targeting effects, as shown by drug penetration and small animal imaging experiments. Target\u2010modified NPs loaded with LCA significantly inhibited tumor growth and prolonged survival in mice. Histological analysis further demonstrated the positive effect of the preparation in reducing lung and liver metastasis lesions. Our study highlights that FA\u2010modified NPs can effectively deliver LCA to the tumor site, enhancing the potential application of LCA to inhibit tumor proliferation and metastasis, and providing new strategies and possibilities for treating triple\u2010negative breast cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202403342","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T19:21:02Z","timestamp":1754940062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Licochalcone A in Folic Acid\u2010targeted Nanoparticles for Precise Anticancer Effects in Breast Cancer"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3940-8759","authenticated-orcid":false,"given":"Hongmei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an P. R. China"},{"name":"School of Pharmacy Jilin Medical University  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiji","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Jilin People's Hospital  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-350X","authenticated-orcid":false,"given":"Xianmin","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Sciences Jilin Medical University  Jilin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"23","author":"Komoto T. T.","year":"2018","journal-title":"Molecules"},{"key":"e_1_2_9_3_1","first-page":"95","article-title":"Effect of BRCA Germline Mutations on Breast Cancer Prognosis","author":"Baretta Z.","year":"2016","journal-title":"Medicine"},{"key":"e_1_2_9_4_1","first-page":"1869","article-title":"Licochalcone A Inhibits PI3K\/Akt\/mTOR Signaling Pathway Activation and Promotes Autophagy in Breast Cancer Cells","volume":"15","author":"Xue L.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076834"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169285"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26131"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030218"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11120731"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471234"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2022.23.1.115"},{"key":"e_1_2_9_14_1","first-page":"13","article-title":"Role of Licochalcone A in Potential Pharmacological Therapy: A Review","author":"Li M.\u2010T.","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200411"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155350"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109335"},{"key":"e_1_2_9_18_1","first-page":"46","article-title":"Preparation, Characterization, Pharmacokinetics, and Antirenal Injury Activity Studies of Licochalcone A\u2010loaded Liposomes","author":"Liu J.","year":"2021","journal-title":"Journal of Food Biochemistry"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15113960"},{"key":"e_1_2_9_20_1","first-page":"3","article-title":"Nanostructured Carriers as Innovative Tools for Cancer Diagnosis and Therapy","author":"Martinelli C.","year":"2019","journal-title":"APL Bioengineering"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.65544"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.032"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500389v"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/BME-130899"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c12641"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2020.1809724"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.08.052"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01097-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.01.039"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21545"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1725025"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117599"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211006171"},{"key":"e_1_2_9_34_1","article-title":"Rutin and Quercetin Counter Doxorubicin\u2010Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2","author":"Ahmed O. M.","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020189"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202403342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:50Z","timestamp":1773008570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202403342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cbdv.202403342"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202403342","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03342"}}