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Therefore, this study aims to evaluate the chemical composition and the anxiolytic and anticonvulsant actions of the <jats:italic>essential oil of Marlierea eugeniopsoides<\/jats:italic> and its majority constituents \u03b1\u2010pinene and \u03b2\u2010pinene. The toxicity was analyzed, and the anxiolytic behavior of fish treated with the oil was assessed in light\/dark tests and open field tests (<jats:italic>n<\/jats:italic>\u00a0=\u00a06 animals\/group). In the test to evaluate the anticonvulsant effect of the sample, pentylenetetrazole (PTZ) was used to induce seizures through immersion. Subsequently, the mechanism of action was investigated with the \u03b3\u2010aminobutyric acid (GABA) antagonist, and molecular docking and ADMET study was conducted. The study revealed that <jats:italic>M. eugeniopsoides<\/jats:italic> oil (spring and summer) was nontoxic and influenced zebrafish locomotion at all doses. Spring oil had anxiolytic effects at all doses, while summer oil showed this only at the highest dose. Both oils affected GABA, with spring oil displaying anticonvulsant properties, unlike summer oil, suggesting a seasonal influence on oil behavior. Molecular docking indicated that inhibitors and ligands interacted beneficially, with \u03b1\u2010pinene demonstrating superior inhibition and cellular permeability.<\/jats:p>","DOI":"10.1002\/cbdv.202403357","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T19:47:50Z","timestamp":1741722470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Anxiolytic and Anticonvulsant Effect of <i>Marlierea eugeniopsoides<\/i> Essential Oils and Its Majority Constituents in Adult Zebrafish"],"prefix":"10.1002","volume":"22","author":[{"given":"Josiane Lima","family":"Mendes","sequence":"first","affiliation":[{"name":"State University of Cear\u00e1, Postgraduate Program in Biotechnology\u2013 Northeast Biotechnology Network (RENORBIO)  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Everson","family":"da 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