{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:04:09Z","timestamp":1778292249937,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>As life pressure mounts, depression cases surge. Conventional antidepressants have limited efficacy and notable side effects. Chuanxiong, a traditional Chinese medicine, orally benefits the nervous system. This study combines traditional aromatherapy with targeted therapy by utilizing small molecular volatile components that quickly enter the brain via the olfactory pathway to investigate the impact of inhaling Chuanxiong volatile oil on depressed mice. We identified the components of Chuanxiong volatile oil, predicted pathways and targets for its antidepressant effects, and elucidated mechanisms affecting hormone levels, the nervous system, and inflammatory responses. Depressed mice inhaling it regained normal weight, had longer open field activity time, more open arm entries in the elevated plus maze, and increased food intake. The detection of serum and brain tissue showed that inhaling Chuanxiong volatile oil effectively restored the levels of inflammatory factors such as interleukin (IL)\u20101\u03b2, IL\u20106, IL\u201010, and IL\u201018, and regulated the interaction between hypothalamic\u2010pituitary\u2010adrenal axis hormones, thereby alleviating the depressive\u2010like symptoms in mice. Brain tissue staining showed that inhaling Chuanxiong volatile oil protected the nervous system. These findings indicate the feasibility of using Chuanxiong volatile oil to treat depression and provide a foundation for using aromatherapy to treat neurological diseases.<\/jats:p>","DOI":"10.1002\/cbdv.202403360","type":"journal-article","created":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T19:43:47Z","timestamp":1753040627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Antidepressant Effects and Mechanisms of Chuanxiong Volatile Oil on Chronic Unpredictable Mild Stress\u2010induced Mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Xia","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujing","family":"Huang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengyang","family":"Ren","sequence":"additional","affiliation":[{"name":"Zhejiang ZEEKR Automobile Research &amp; Development Co., Ltd  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3044-3425","authenticated-orcid":false,"given":"Qinglei","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Perfume &amp; Aroma and Cosmetics of the Ministry of Education, School of Perfume and Aroma Technology Shanghai Institute of Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31948\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12844"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.12.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119960"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.12.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115595683"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210219161747"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.832673"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117337"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113888"},{"key":"e_1_2_9_12_1","first-page":"3241","article-title":"Mechanisms Underlying the Beneficial Effects of Kaiyu Granule for Depression","volume":"8","author":"Jin X.","year":"2013","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117058"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.815891"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112053"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031944"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21847"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-16"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187257"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.188"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170911121027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245227"},{"key":"e_1_2_9_24_1","article-title":"Norepinephrine Dysfunction in Depression","author":"Anand A.","year":"2000","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1479"},{"key":"e_1_2_9_27_1","first-page":"30","article-title":"Tumor Necrosis Factor Inhibitor Therapy and the Risk for Depression Among Working\u2010Age Adults with Rheumatoid Arthritis","volume":"12","author":"Deb A.","year":"2019","journal-title":"American Health & Drug Benefits"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2201014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-022-00625-z"}],"container-title":["Chemistry &amp; 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