{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:36:43Z","timestamp":1783247803484,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammation is a vital immune response to injury, infection, or harmful stimuli, and prolonged inflammation leads to various disorders. Traditional medicinal systems such as Ayurveda offer a rich repository of plant\u2010based remedies for inflammatory conditions. In this study, 18 medicinal plants were screened for anti\u2010inflammatory potential using in vitro and in vivo assays. Methanolic extracts and solvent\u2010partitioned fractions were evaluated for cytotoxicity, nitric oxide (NO) inhibition, pro\u2010inflammatory cytokines (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , IL\u20106, tumor necrosis factor\n                    <jats:italic>\u03b1<\/jats:italic>\n                    [TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ]), nuclear factor\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B), and COX\u20102 inhibition in LPS\u2010stimulated RAW 264.7 murine macrophages. Six promising extracts\/fractions were further tested in vivo using carrageenan\u2010induced rat paw edema model. Extracts of\n                    <jats:italic>Adenanthera microsperma<\/jats:italic>\n                    ,\n                    <jats:italic>Physalis minima<\/jats:italic>\n                    ,\n                    <jats:italic>Rhododendron arboreum<\/jats:italic>\n                    ,\n                    <jats:italic>Schleichera oleosa<\/jats:italic>\n                    , and\n                    <jats:italic>Volkameria inermis<\/jats:italic>\n                    exhibited significant anti\u2010inflammatory activity in rat paw edema as compared to indomethacin. Marker compounds, quercitrin (1.06% w\/w), physalin H (0.101% w\/w), hyperoside (0.36% w\/w), betulinic acid (0.60% w\/w), and acacetin (0.58% w\/w), were isolated using column chromatography and confirmed in the respective bioactive extracts\/fractions by analytical HPLC using a spiking method. These phytoconstituents have been reported to modulate inflammatory pathways, including NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B and MAPK signaling. The study provides experimental validation of traditional claims and highlights these plants as promising candidates for the development of anti\u2010inflammatory therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403382","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:13:40Z","timestamp":1751555620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selected Indian Medicinal Plants Exhibit Anti\u2010Inflammatory Activity by Modulating Pro\u2010Inflammatory Cytokines In Vitro and in Carrageenan\u2010Induced Rat Paw Edema"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0546-2403","authenticated-orcid":false,"given":"Shreyanshi","family":"Kulshreshtha","sequence":"first","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research (NIPER)  SAS Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9901-787X","authenticated-orcid":false,"given":"Yogita B.","family":"Tandalekar","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research (NIPER)  SAS Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0088-6403","authenticated-orcid":false,"given":"Alok","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research (NIPER)  SAS Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0737-0908","authenticated-orcid":false,"given":"Amit K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research (NIPER)  SAS Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-137X","authenticated-orcid":false,"given":"Sanjay M.","family":"Jachak","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research (NIPER)  SAS Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.11.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13040874"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163726"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253\u20107613.178831"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5493\/wjem.v5.i2.64"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.05.004"},{"key":"e_1_2_13_8_1","first-page":"1251","article-title":"Challenges and Opportunities in Drug Discovery From Plants","volume":"92","author":"Jachak S. M.","year":"2007","journal-title":"Current Science"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010019\u201009629\u20109"},{"key":"e_1_2_13_10_1","first-page":"172","article-title":"Role of Natural Products in Drug Discovery Process","volume":"6","author":"Siddiqui A. A.","year":"2014","journal-title":"International Journal of Drug Development and Research"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.10.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.38212\/2224\u20106614.2748"},{"key":"e_1_2_13_13_1","volume-title":"The Wealth of India, a Dictionary of Indian Raw Materials and Industrial Products, Vol. 1A","author":"Chadha Y. R.","year":"1985"},{"key":"e_1_2_13_14_1","first-page":"1404","article-title":"Phytochemical and Pharmacological Revire on Annona squamosa Linn","volume":"2","author":"Pandey N.","year":"2011","journal-title":"International Journal of Research in Pharmaceutical and Biomedical Sciences"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.31254\/phyto.2014.3109"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2017.3.63"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines7110069"},{"key":"e_1_2_13_18_1","first-page":"14902","article-title":"Ethnomedicinal and Pharmacological Uses of Curcuma caesia","volume":"8","author":"Sharma P.","year":"2021","journal-title":"Natural Volatiles and Essential Oils"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.22271\/plants.2024.v12.i1b.1633"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR10.977"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajidsp.2009.180.182"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.020"},{"key":"e_1_2_13_23_1","first-page":"477","article-title":"A Phyto\u2010Pharmacological Overview on Physalis minima Linn","volume":"3","author":"Chothani D. L.","year":"2012","journal-title":"Indian Journal of Natural Products and Resources"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.12032\/TMR20201218212"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010009\u20100336\u20106"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596\u2010017\u20100289\u20103"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.09.001"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopr.2012.11.003"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/2215083803666170502120028"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010024\u201009934\u2010y"},{"key":"e_1_2_13_31_1","unstructured":"National Medicinal Plant Board Ministry of AYUSH Government of India https:\/\/echarak.ayush.gov.in\/ accessed October 15 2024."},{"key":"e_1_2_13_32_1","volume-title":"Medicinal Plants Used in Ayurveda, Rashtriya Ayurveda Vidyapeeth, Ministry of Health & Family Welfare","author":"Sharma S. K.","year":"1998"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198943"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.06.027"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010022\u201001584\u20100"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-374-7:115"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00117"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021082"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14081609"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.5.0679"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.7.3963"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7039802"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111789"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.7"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.883857"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1286546"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202403382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202403382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:25:16Z","timestamp":1773008716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202403382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cbdv.202403382"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202403382","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03382"}}