{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:47:42Z","timestamp":1773280062913,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004172","name":"Mersin \u00dcniversitesi","doi-asserted-by":"publisher","award":["BAP 2018\u20102\u2010AP4\u20103013"],"award-info":[{"award-number":["BAP 2018\u20102\u2010AP4\u20103013"]}],"id":[{"id":"10.13039\/501100004172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to integrate the ethanolic extract obtained from the aerial parts of endemic\n                    <jats:italic>Onosma rutila<\/jats:italic>\n                    as a new bioactive ingredient into polymeric films and to produce biofunctional composite thin films for use in biomedical applications. Initially, the definition of the plant extract was carried out in terms of chemical composition and biological activities. The main component of the extract was revealed as 9,12\u2010octadecadienoic acid (15.90%). Antimicrobial activity was evaluated against a total of five microorganisms by the\u00a0well diffusion method and microdilution technique. MIC99 results showed the lowest inhibition against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , suggesting a stronger antifungal effect than antibacterial activity. Also, the 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl scavenging activity of\n                    <jats:italic>O. rutila<\/jats:italic>\n                    , ascorbic acid, and butylated hydroxytoluene at 500\u00a0\u00b5g\/mL showed values \u200b\u200bof 87.63, 90.13, and 46.82%, respectively. In the next phase, the extract, which was revealed to be an effective biological agent, was incorporated into the polymer solutions prepared based on chitosan and polyvinyl alcohol at different ratios to produce a series of thin films. For application purposes, the thin films' chemical compositions, water retention capacities, and morphological properties\u00a0were determined and their potential for use as wound dressing material was evaluated.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403403","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:36:48Z","timestamp":1739237808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Onosma rutila<\/i>\n                    (Boraginaceae) Plant Extract: Chemical Composition, Biological Analysis, and Film Forming Potential With Polymers"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-8305","authenticated-orcid":false,"given":"Riza","family":"Binzet","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science Mersin University Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-9528","authenticated-orcid":false,"given":"Gun","family":"Binzet","sequence":"additional","affiliation":[{"name":"Department of Elementary Science Education, Faculty of Education Mersin University  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-9020","authenticated-orcid":false,"given":"Ersan","family":"Turunc","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Technical Science Vocational School, Mersin University  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-6096","authenticated-orcid":false,"given":"P\u0131nar K\u00fcce","family":"Cevik","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Science Harran University  Sanliurfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-2077","authenticated-orcid":false,"given":"Didem","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Process Technologies Mersin Tarsus Organized Industrial Zone Technical Sciences Vocational School, Tarsus University  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-9442","authenticated-orcid":false,"given":"Hakan","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Mersin University  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"A.G\u00fcner(ed.).A Checklist of the Flora of Turkey (Vascular Plants). Nama\u015f Nurtan Ambalaj ve Matbaac\u0131l\u0131k San. ve Tic. A.\u015e. 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