{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:23:39Z","timestamp":1783092219840,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five pregnane C\n                    <jats:sub>21<\/jats:sub>\n                    \u2010steroids, including three 5,6\u2010epoxy steroids (\n                    <jats:bold>1\u22123<\/jats:bold>\n                    ) and two 8,14\u2010\n                    <jats:italic>seco<\/jats:italic>\n                    \u2010steroids (\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    ), were isolated from the acid hydrolysate of\n                    <jats:italic>Cynanchum bungei<\/jats:italic>\n                    roots. Cynbungenins L\u2010O (\n                    <jats:bold>1\u22124<\/jats:bold>\n                    ) are previously undescribed compounds. Compound\n                    <jats:bold>3<\/jats:bold>\n                    with a 5\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ,6\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010epoxy group represents the first example found in the\n                    <jats:italic>Cynanchum<\/jats:italic>\n                    plants. Their structures and absolute configurations were elucidated by a variety of spectroscopic analysis and theoretical ECD calculations. All compounds (\n                    <jats:bold>1\u20135<\/jats:bold>\n                    ) were evaluated for their anti\u2010inflammatory activity by inhibiting the lipopolysaccharide (LPS)\u2010induced nitric oxide (NO) released in RAW264.7 cells. The results showed that they all possessed NO inhibitory activity at 50\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M, and compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    exhibited stronger NO inhibitory activity than indomethacin.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403412","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T11:24:06Z","timestamp":1736162646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pregnane C\n                    <sub>21<\/sub>\n                    \u2010Steroids with Anti\u2010Inflammatory Activity from the Roots of\n                    <i>Cynanchum bungei<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-5968","authenticated-orcid":false,"given":"Xiao\u2010San","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&amp;D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang P. R. China"},{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang  Zhanjiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Bin","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Bi","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&amp;D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong\u2010Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&amp;D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Tao","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&amp;D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai\u2010Yun","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Zhanjiang University of Science and Technology  Zhanjiang P. R. 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