{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:09:39Z","timestamp":1776758979955,"version":"3.51.2"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We reported the synthesis of novel pyrazole amide derivatives. The newly synthesized compounds are exhibiting\u00a0in vitro anti\u2010cancer efficacy against MCF\u20107 and A\u2010549 human cancer cell lines. The compounds,\n                    <jats:bold>6m<\/jats:bold>\n                    ,\n                    <jats:bold>6o<\/jats:bold>\n                    , and\n                    <jats:bold>6p<\/jats:bold>\n                    have greater activity against A\u2010549 cell lines with reference to 5\u2010Fluorouracil. Similarly, in vitro, epidermal growth factor receptor results revealed that compounds\n                    <jats:bold>6p<\/jats:bold>\n                    (50% inhibitory concentration [IC\n                    <jats:sub>50<\/jats:sub>\n                    ] = 0.79 \u00b1\u00a00.04 \u00b5M) and\n                    <jats:bold>6m<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.86 \u00b1\u00a00.06 \u00b5M) have shown improved activity in comparison to the standard Erlotinib (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.41 \u00b1\u00a00.03 \u00b5M). This article systematically examines the docking studies of lead compounds\n                    <jats:bold>6i<\/jats:bold>\n                    ,\n                    <jats:bold>6m<\/jats:bold>\n                    ,\n                    <jats:bold>6o<\/jats:bold>\n                    , and\n                    <jats:bold>6p<\/jats:bold>\n                    , finally found compound\n                    <jats:bold>6o<\/jats:bold>\n                    showing better binding properties (\u201010.85\u00a0kcal) among all.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403418","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:53:21Z","timestamp":1744286001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Biological Evaluation of 1\u2010(4\u2010(Methylsulfonyl)Phenyl)\u20105\u2010Phenyl\u20101H\u2010Pyrazole\u20104\u2010Carboxamides as Epidermal Growth Factor Receptor\u2010Targeting Anticancer Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Madhava Rao","family":"Bandaru","sequence":"first","affiliation":[{"name":"Department of Chemistry GITAM School of Science GITAM (Deemed to be) University  Hyderabad India"},{"name":"Department of Chemistry GITAM School of Science GITAM (Deemed to be) University  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-3173","authenticated-orcid":false,"given":"Muvvala","family":"Venkatanarayana","sequence":"additional","affiliation":[{"name":"Department of Chemistry GITAM School of Science GITAM (Deemed to be) University  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Basava","sequence":"additional","affiliation":[{"name":"Department of Chemistry GITAM School of Science GITAM (Deemed to be) University  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharath Babu","family":"Haridasyam","sequence":"additional","affiliation":[{"name":"Department of Chemistry GITAM School of Science GITAM (Deemed to be) University  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd15.180151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28944"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060739"},{"key":"e_1_2_10_6_1","first-page":"433","article-title":"Small Molecules for Immunomodulation in Cancer: A Review Anticancer Agents","volume":"15","author":"Iyer V. 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