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Then, the CA isozymes were isolated and the inhibitory effects of the synthesized derivatives on these enzymes were investigated experimentally. The mechanism of inhibition was estimated by molecular docking studies. Finally, the Absorption, Distribution, Metabolism, and Excretion properties of derivatives were evaluated and analyzed in terms of pharmacokinetics and drug similarity. <jats:bold>P4<\/jats:bold> was the most effective inhibitor among derivatives against both hCA\u2010I and hCA\u2010II with K<jats:sub>i<\/jats:sub> constants as 0.22 \u00b1 0.01 and 0.33 \u00b1 0.05\u00a0\u00b5M, respectively. Besides, <jats:bold>P4<\/jats:bold> had a higher binding affinity to both enzymes with free binding energies of \u20108.14 and \u20108.03\u00a0kcal\/mol. According to drug\u2010likeness analysis, it was predicted that the derivatives comply with Lipinski's rule of five without any deviation.<\/jats:p>","DOI":"10.1002\/cbdv.202403435","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:23:08Z","timestamp":1748380988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Carbonic Anhydrase Inhibition Profiles of <i>N<\/i>\u2010(3\u2010sulfamoylphenyl)propanamide\/benzamide Derivatives: Experimental and Computational Insights With Absorption, Distribution, Metabolism, and Excretion Profiling"],"prefix":"10.1002","author":[{"given":"Ferhat","family":"G\u00fcne\u015f","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Atat\u00fcrk University Faculty of Pharmacy  Erzurum T\u00fcrkiye"},{"name":"Department of Pharmaceutical Chemistry, Gazi University Institute of Health Sciences  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"G\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, I\u011fd\u0131r University Faculty of Engineering  I\u011fd\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"G\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Atat\u00fcrk University Faculty of Sciences  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bari\u015f","family":"Anil","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Atat\u00fcrk University Faculty of Sciences  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-5925","authenticated-orcid":false,"given":"Mehmet","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Atat\u00fcrk University Faculty of Pharmacy  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2012.tb00415.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.2004.01361.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.707646"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/bdd.2309","article-title":"In vitro and In Silico Interactions of Antiulcer, Glucocorticoids and Urological Drugs on Human Carbonic Anhydrase I and II Isozymes","volume":"43","author":"G\u00fcller U.","year":"2022","journal-title":"Biopharmaceutics & Drug Disposition"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.10.5.575"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.780598"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151739"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1136\/thx.49.11.1096","article-title":"Effect of Acetazolamide and Amiloride Against Sodium Metabisulphite\u2010Induced Bronchoconstriction in Mild Asthma","volume":"49","author":"O'Connor B. 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