{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:52Z","timestamp":1786977352237,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The benzoxazoles and benzothiazoles derivatives have a variety of pharmacological activities, such as antimicrobial activity. Thus, in the present study, the antifungal activity of 13 benzoxazole and benzothiazole derivatives against\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. strains were evaluated. Compound\n                    <jats:bold>1<\/jats:bold>\n                    presented strong antimicrobial action for\n                    <jats:italic>C. krusei<\/jats:italic>\n                    with MIC of 15.6 \u00b5g\/mL, activities against strains of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    (62.5 \u00b5g\/mL), and\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    (125.0 \u00b5g\/mL). In addition, it was evidenced that biological activity occurs in the plasma membrane in\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . The results of the in silico study showed that the predicted inhibition of HSP90 and aldehyde dehydrogenase could explain the antifungal activity of Compound\n                    <jats:bold>1<\/jats:bold>\n                    . New derivatives can be synthesized from the functionalization of these chemical structures and may result in more potent antifungal compounds, in addition to advancing the investigation of the mechanism of action. Therefore, the data highlight the potential of these compounds in the search for antimicrobial drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202403459","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T08:51:16Z","timestamp":1742028676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antifungal Evaluation of Benzoxazole and Benzothiazole Derivatives: An In Vitro and In Silico Study"],"prefix":"10.1002","volume":"22","author":[{"given":"Jeremias Justo","family":"Em\u00eddio","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Henrique Xavier","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology and Cell Culture, Department Clinical and Social Dentistry Federal University of Paraiba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Dias","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology and Cell Culture, Department Clinical and Social Dentistry Federal University of Paraiba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunierkis","family":"Perez\u2010Castillo","sequence":"additional","affiliation":[{"name":"Bio\u2010Cheminformatics Research Group Universidad de Las Am\u00e9ricas  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o Pergentino","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S118892"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-014-1003-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02173"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9060669"},{"issue":"2","key":"e_1_2_10_6_1","article-title":"Epidemiology, and Antifungal Susceptibility of Candida Species in a Tertiary Care Hospital","volume":"2","author":"Bhattacharjee P.","year":"2016","journal-title":"Current Medical Mycology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.076"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.33448\/rsd-v10i4.14283","article-title":"Genus Candida\u2010Virulence Factors, Epidemiology, Candidiasis and Mechanisms of Resistance","volume":"10","author":"Da Rocha W. 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