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Among the various click reactions, the copper(I)\u2010catalyzed azide\u2010alkyne cycloaddition (CuAAC) has emerged as the most widely used technique. The formation of 1,2,3\u2010triazoles through copper(I)\u2010catalyzed reactions between azides and terminal acetylenes serves as an effective method for creating important medicinal frameworks. This process is highly reliable, completely specific, and utilizes biocompatible reagents. Click chemistry has emerged as a valuable approach for developing potential anticancer drug candidates. The present review highlights the recent advancements (2020\u20132025) in the click chemistry approach (CuAAC) for the construction of biologically important triazole moieties and their hybrid compounds as anticancer agents.<\/jats:p>","DOI":"10.1002\/cbdv.202403462","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:38:48Z","timestamp":1740127128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Recent Advancements in CuAAC Click Approaches for the Synthesis of 1,2,3\u2010Triazole Hybrid Compounds as Anticancer Agents"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-4755","authenticated-orcid":false,"given":"Sherif Shaban","family":"Ragab","sequence":"first","affiliation":[{"name":"Photochemistry Department, Chemical Industries Research Institute National Research Centre, El\u2010Buhouth St. Dokki Giza Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Click Chemistry: Fundamentals and Synthesis","author":"Gupta R. 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