{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:17:07Z","timestamp":1768479427180,"version":"3.49.0"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Dinizia excelsa<\/jats:italic>, an Amazonian tree from the Fabaceae family, is valued for its wood, yet its biological potential is underexplored. This study analyzed its essential oil (EO), revealing 48 compounds, notably pulegone (25.3%), \u03b1\u2010cedrol (12.87%), and thymol (11.5%). Absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters indicated good oral bioavailability and low toxicity. The oil exhibited moderate antioxidant activity (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a0124.87\u00a0\u00b5g\/mL) and low cytotoxicity (IC<jats:sub>50<\/jats:sub>\u00a0&gt;\u00a088\u00a0\u00b5g\/mL), with hemolysis below 5%. It promoted cell proliferation and increased CD8+ lymphocytes, with antitumor activity ranging from IC<jats:sub>50<\/jats:sub>\u00a0=\u00a019.0\u201357.9\u00a0\u00b5g\/mL, particularly effective against HCT\u20108 (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a019.0\u00a0\u00b5g\/mL). The oil showed antimicrobial action against <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumonia<\/jats:italic> (minimum inhibitory concentration [MIC]\u00a0=\u00a0512\u00a0\u00b5g\/mL) and trypanocidal effects against <jats:italic>Trypanosoma cruzi<\/jats:italic> (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a034.34\u00a0\u00b5g\/mL) and <jats:italic>Leishmania amazonensis<\/jats:italic> (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a033.79\u00a0\u00b5g\/mL). It also reduced the motility of adult schistosomes by 81.25% at 200\u00a0\u00b5g\/mL. <jats:italic>D. excelsa<\/jats:italic> EO has pharmaceutical potential for anti\u2010inflammatory, antitumor, and antiparasitic applications, enhancing Amazonian biodiversity.<\/jats:p>","DOI":"10.1002\/cbdv.202403474","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:13:29Z","timestamp":1741713209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Biological Activities of <i>Dinizia excelsa<\/i> Wood Essential Oil: A Potential Phytotherapeutic Agent"],"prefix":"10.1002","volume":"22","author":[{"given":"J\u00falia Concei\u00e7\u00e3o Bezerra","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-1738","authenticated-orcid":false,"given":"Diego Santa Clara","family":"Marques","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Crystina Costa","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandra","family":"da Silva Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Van Lauter Albuquerque","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio A. B.","family":"Santos","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (IAM\u2010FIOCRUZ) Cidade Universit\u00e1ria  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Alves","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (IAM\u2010FIOCRUZ) Cidade Universit\u00e1ria  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Alves","family":"de Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iranildo Jos\u00e9 da","family":"Cruz Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Therapeutic Innovation Department of Antibiotics Federal University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"30","article-title":"Tratamento t\u00e9rmico De madeira serrada do angelim pedra (Dinizia excelsa Ducke) com boro","volume":"2","author":"Bara\u00fana E. 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