{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:07Z","timestamp":1753862827306,"version":"3.41.2"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Salvia sclarea<\/jats:italic> L., commonly known as clary sage, belongs to the most popular species of Salvia. Traditionally, it has been utilized as a spasmolytic, antiseptic, and anti\u2010inflammatory agent. Many studies have evaluated its anti\u2010inflammatory, analgesic, antimicrobial, and cytotoxic effects. Remarkably, no study has yet assessed its potential hepatoprotective activity. The evaluation of in vitro antioxidant activity was done using spectrophotometric methods. The extract's impact on biochemical markers of liver injury, antioxidant enzyme activity, and liver morphology was evaluated in Swiss Albino mice with paracetamol (PCM)\u2010induced hepatotoxicity. Gas chromatography\u2013mass spectroscopy (GC\u2013MS) analysis of the chloroform\u2013methanolic extract of <jats:italic>S. sclarea<\/jats:italic> L. roots (SSR\u2010CM) revealed the presence of several phytochemicals, with ferruginol and its ester showing the highest retention time. SSR\u2010CM exhibited significant, concentration\u2010dependent antioxidant effect, though weaker than the standard antioxidants. Its oral administration at 200 milligrams (mg)\/kg\/day demonstrated a significant decrease in PCM\u2010induced elevated alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels. Enhanced catalase, superoxide dismutase, and glutathione reductase activities were observed in SSR\u2010CM and silymarin\u2010treated groups, along with histopathological evidence of reduced hepatocellular damage compared to the PCM\u2010only group. Overall, these findings suggest that SSR\u2010CM holds potential as a natural hepatoprotective agent and offer valuable insights into its chemical composition.<\/jats:p>","DOI":"10.1002\/cbdv.202403496","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T18:50:52Z","timestamp":1748631052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Profiling and Hepatoprotective Potential of Chloroform\u2013Methanolic Extract of <i>Salvia sclarea<\/i> L.: GC\u2013MS Analysis and In Vivo Studies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-6408","authenticated-orcid":false,"given":"Nasir","family":"Nisar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Kashmir  Srinagar Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Maqbool","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Kashmir  Srinagar Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-8434","authenticated-orcid":false,"given":"Suhail Ahmad","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Kashmir  Srinagar Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Showkat Ahmad","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Veterinary Pathology FVSc &amp; AH, SKUAST\u2010K  Srinagar Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-0323","authenticated-orcid":false,"given":"Nahida","family":"Tabassum","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Kashmir  Srinagar Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100311"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091653"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S259081"},{"key":"e_1_2_9_6_1","first-page":"1239","article-title":"Epidemiology and Management of Drug\u2010Induced Liver Injury: Importance of the Updated RUCAM","volume":"11","author":"Kobayashi T.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2024.101727"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43066-023-00248-w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51661-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065179"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11202690"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195757"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2015.1130705"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.889720"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.08.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59755"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215570992"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.07.030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess17187"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2005.10.008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.54.2.28"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11240-005-9018-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.997233"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735414555806"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.2.0014"},{"key":"e_1_2_9_26_1","first-page":"308","article-title":"Immunomodulatory Effects of Plant Extracts From Salvia deserta Schang. and Salvia sclarea L.","volume":"10","author":"Zhu X.\u2010Y.","year":"2020","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4234061"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105313"},{"key":"e_1_2_9_29_1","first-page":"315","article-title":"Terpenoids From Juniperus Procera With Hepatoprotective Activity","volume":"25","author":"Alqasoumi S. 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