{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:07:59Z","timestamp":1791223679597,"version":"4.1.0"},"reference-count":177,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study investigated the phytochemical composition of <jats:italic>Thymus capitatus<\/jats:italic> L. essential oil (TCEO) harvested in Morocco using GC\u2013MS\u2013MS analysis. Both in vitro and in silico approaches were combined to investigate the antioxidant, antibacterial, antidiabetic, dermatoprotective, and neuroprotective properties of TCEO as well as to identify the main compounds responsible of the promising properties. The TCEO was dominated by oxygenated monoterpene (63.33%) and monoterpene hydrocarbon (23.25%). In total, 20 volatile compounds were identified, and of them, carvacrol, thymol, <jats:italic>p<\/jats:italic>\u2010cymene, \u03b3\u2010terpinene, caryophyllene, and linalool are the major compounds. Then, the study of the antioxidant activity revealed that TCEO exhibits a good activity in DPPH, ABTS, and FRAP assays as the obtained values were 67.34\u00a0\u00b1\u00a01.54, 96.88\u00a0\u00b1\u00a02.76, and 99.07\u00a0\u00b1\u00a01.57\u00a0\u00b5g\/mL, respectively, compared to those of Trolox (35.38\u00a0\u00b1\u00a00.91, 60.40\u00a0\u00b1\u00a01.55, and 52.13\u00a0\u00b1\u00a01.56\u00a0\u00b5g\/mL, respectively). The antibacterial activity revealed that TCEO was the most active toward the two Gram\u2010positive bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Listeria monocytogenes<\/jats:italic>) with minimum inhibitory concentration (MIC) of 0.125% each compared to Gram\u2010negative ones (<jats:italic>Pseudomonas aeruginosa<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>) with MIC of 0.25% and 0.5%, respectively. For the antidiabetic tests, TCEO displayed markedly lower IC<jats:sub>50<\/jats:sub> values, 111.79\u00a0\u00b1\u00a02.88\u00a0\u00b5g\/mL for \u03b1\u2010amylase and 70.42\u00a0\u00b1\u00a01.68\u00a0\u00b5g\/mL for \u03b1\u2010glucosidase than those of acarbose (389.04\u00a0\u00b1\u00a01.65 and 187.82\u00a0\u00b1\u00a02.62\u00a0\u00b5g\/mL, respectively). For anti\u2010elastase activity, TCEO exhibited an IC<jats:sub>50<\/jats:sub> value of 42.58\u00a0\u00b1\u00a01.72\u00a0\u00b5g\/mL, indicating moderate inhibitory potency, whereas quercetin demonstrated a significantly stronger effect with an IC<jats:sub>50<\/jats:sub> of 11.81\u00a0\u00b1\u00a00.90\u00a0\u00b5g\/mL. In terms of anti\u2010tyrosinase activity, TCEO showed an IC<jats:sub>50<\/jats:sub> of 85.55\u00a0\u00b1\u00a02.51\u00a0\u00b5g\/mL, which is notably more effective than quercetin's IC<jats:sub>50<\/jats:sub> of 242.99\u00a0\u00b1\u00a02.67\u00a0\u00b5g\/mL. The study of neuroprotection ability revealed that TCEO exerted a good effect as the inhibition of acetylcholinesterase (AChE) was 12.36\u00a0\u00b1\u00a00.93\u00a0mg GALAE\/g, whereas that of butyrylcholinesterase (BChE) was 3.59\u00a0\u00b1\u00a00.64\u00a0mg GALAE\/g. On the basis of these findings, it is believed that TCEO can serve as a readily available reservoir of natural antioxidants and antibacterial chemicals. TCEO could also provide considerable benefits for health, including antidiabetic, dermatoprotection, and neuroprotection capacities.<\/jats:p>","DOI":"10.1002\/cbdv.202403501","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T15:28:17Z","timestamp":1742657297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Volatile Compounds and Biological Effects Capacities of Moroccan <i>Thymus capitatus<\/i> L., Essential Oils: In Vitro and In Silico Approaches"],"prefix":"10.1002","author":[{"given":"Tarik","family":"Aanniz","sequence":"first","affiliation":[{"name":"Biotechnology Laboratory (MedBiotech) Bioinova Research Center Rabat Medical and Pharmacy School Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Elouafy","sequence":"additional","affiliation":[{"name":"Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-1631","authenticated-orcid":false,"given":"Abdelhakim","family":"Bouyahya","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumayma","family":"Aguerd","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Chamkhi","sequence":"additional","affiliation":[{"name":"Agrobiosciences Program University Mohammed VI Polytechnic Ben Guerir Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy College of Pharmacy, King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essam A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy, King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Akhazzane","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sidi Mohamed Ben Abdellah F\u00e8s Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufiq","family":"Benali","sequence":"additional","affiliation":[{"name":"Laboratory of Ecotoxicology, Bioresources, and Coastal Geomorphology, Polydisciplinary Faculty of Safi Cadi Ayyad University Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2022.102422"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31033\/abjar.2.5.2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"issue":"5","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/antibiotics10050593","article-title":"Bacterial Resistance to Antimicrobial Agents","volume":"10","author":"Varela M. 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