{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:10:01Z","timestamp":1782961801663,"version":"3.54.5"},"reference-count":194,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hesperidin, a bioflavonoid abundantly found in citrus fruits, offers a myriad of health benefits. With the food industry extensively utilizing citrus fruits, particularly for juice production, substantial quantities of by\u2010products such as peels, seeds, cells, and membrane residues accumulate. Remarkably, these by\u2010products serve as a valuable source of hesperidin. Consequently, the extraction of hesperidin from these by\u2010products has garnered significant scientific interest, aiming to harness its potential as a natural antioxidant. By shedding light on these aspects, this review provides a comprehensive review of hesperidin's role in enhancing human well\u2010being, particularly in the context of chronic fatigue syndrome (CFS). By synthesizing current research, we elucidate the compound's antioxidant, anti\u2010inflammatory, and neuroprotective effects, which may mitigate symptoms associated with CFS. Furthermore, we introduce machine learning methodologies to predict hesperidin's efficacy in clinical settings, offering a novel perspective on personalized nutrition strategies. Our findings underscore the need for further empirical studies to validate these predictions and explore hesperidin's mechanisms of action. This review not only bridges the gap between nutrition science and pharmacology but also highlights the promising future of hesperidin as a nutraceutical in combating chronic health conditions.<\/jats:p>","DOI":"10.1002\/cbdv.202403506","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T22:11:21Z","timestamp":1744755081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hesperidin in Chronic Fatigue Syndrome: An Integrated Analysis of Traditional Pharmacology and Machine Learning\u2013Based Therapeutic Predictions"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-3352","authenticated-orcid":false,"given":"Riham A.","family":"El\u2010Shiekh","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University Cairo Egypt"},{"name":"Faculty of Pharmacy King Salman International University (KSIU) South Sinai Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-3441","authenticated-orcid":false,"given":"Asmaa A.","family":"Mandour","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Future University in Egypt (FUE) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam M.","family":"Adel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Atwa","sequence":"additional","affiliation":[{"name":"College of Pharmacy Al\u2010Ayen Iraqi University, AUIQ An Nasiriyah Iraq"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Egyptian Russian University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Elgindy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Egyptian Russian University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar M.","family":"Esmail","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Egyptian Russian University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Magdy","family":"Senna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Egyptian Russian University Cairo 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