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Five novel 4\u2010methoxyglucosides, one new non\u2010nucleoside cyclic peptide and 36 known compounds were isolated from the ethanol extract of the fermentation products. Notably, in the five novel glucosides, the 4\u2010position hydroxyl group was modified to a methoxy group, likely due to enzymatic reactions during fermentation. In vitro assays revealed that compounds <jats:bold>4<\/jats:bold>, <jats:bold>5<\/jats:bold>, <jats:bold>16<\/jats:bold>, <jats:bold>19<\/jats:bold>, <jats:bold>20<\/jats:bold>, <jats:bold>25<\/jats:bold>, <jats:bold>27<\/jats:bold>, <jats:bold>31<\/jats:bold>, and <jats:bold>37<\/jats:bold> exhibited inhibitory effects on A549 cells, with the IC<jats:sub>50<\/jats:sub> values for the known compound <jats:bold>31<\/jats:bold> being 38.5\u00a0\u00b5M.<\/jats:p>","DOI":"10.1002\/cbdv.202500009","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T07:00:03Z","timestamp":1749106803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New 4\u2010Methoxyglucosides With Anti\u2010A549 Activity From Bidirectional Solid Fermentation of <i>Scutellaria barbata<\/i> and <i>Cordyceps kyushuensis<\/i>"],"prefix":"10.1002","author":[{"given":"Huixin","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Si","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-630X","authenticated-orcid":false,"given":"Guoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianya","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"State Key Laboratory of Microbial Technology Shandong University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"48","article-title":"Enhancement of Arctigenin Content by Processing of Fructus arctii via Solid\u2010State Fermentation Coupled With Poach","volume":"30","author":"Ou Z.","year":"2009","journal-title":"Chinese Journal of Catalysis"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.124566"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63504-4.00023-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.12.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112260"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.03.025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050826"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2018.09.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-008-9440-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97922-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.powtec.2012.12.038","article-title":"Soluplus: A Novel Polymeric Solubilizer for Optimization of Carvedilol Solid Dispersions: Formulation Design and Effect of Method of Preparation","volume":"237","author":"Shamma R. 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