{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:33:32Z","timestamp":1787974412327,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Nephrolithiasis, or kidney stone formation, is a widespread global health concern. This study examines the effects of polyphenolic extracts, along with their anthocyanin and non\u2010anthocyanin fractions, from sumac fruit, pomegranate peel, almond leaves, falsa fruit, and banana bracts on the crystallization of calcium oxalate (CaC<jats:sub>2<\/jats:sub>O<jats:sub>4<\/jats:sub>\u00b7nH<jats:sub>2<\/jats:sub>O) and brushite (CaHPO<jats:sub>4<\/jats:sub>\u00b72H<jats:sub>2<\/jats:sub>O) in vitro. The extracts were prepared through maceration in aqueous methanol and further fractionated into anthocyanin and non\u2010anthocyanin fractions using solid\u2010phase extraction. For calcium oxalate crystallization, nucleation and aggregation were monitored using a spectrophotometer in the presence and absence of these extracts and fractions. For brushite crystallization, the single diffusion gel growth method was employed. All extracts inhibited the crystallization of both calcium oxalate and brushite in a dose\u2010dependent manner, significantly reducing crystal number, size, and altering crystal morphology. Non\u2010anthocyanin fractions demonstrated a stronger inhibitory effect than anthocyanin fractions. Molecular docking studies further revealed that compounds in these fractions exhibited strong binding affinity with proteins involved in the adhesion and aggregation of calcium oxalate crystals to renal cells, supporting their antilithogenic properties. These findings suggest that these natural polyphenolic sources hold promise as potential inhibitors of kidney stone formation.<\/jats:p>","DOI":"10.1002\/cbdv.202500023","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:40:00Z","timestamp":1741740000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Polyphenolic Extracts From Sumac, Pomegranate Peel, Indian Almond Leaves, Falsa, and Banana Bracts on Calcium Oxalate and Brushite Crystallization In Vitro"],"prefix":"10.1002","volume":"22","author":[{"given":"Mudassir","family":"Nazir","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Technology University of Karachi  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdul","family":"Haq","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology University of Karachi  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Moahida Batool","family":"Sherazi","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology University of Karachi  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahina","family":"Naz","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology University of Karachi  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Mobin","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology University of Karachi  Karachi Sindh Pakistan"},{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-9778","authenticated-orcid":false,"given":"Alexandros","family":"Tsoupras","sequence":"additional","affiliation":[{"name":"Hephaestus Laboratory, School of Chemistry Faculty of Science, Democritus University of Thrace, University of Thrace, Kavala University Campus  St Lukas Kavala Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0960-5"},{"issue":"3","key":"e_1_2_8_3_1","article-title":"Global Chronickidney Disease\u2010Related Death Burden and Attributable Risk Factors From 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019","volume":"13","author":"Guo Y.","year":"2023","journal-title":"BMJ Open"},{"key":"e_1_2_8_4_1","unstructured":"S. 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