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Compounds with 4\u2010nitro and 4\u2010chloro groups, respectively, proved the most significant, promising <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibition activity with IC<jats:sub>50<\/jats:sub> values of 3.35 and 6.58 \u00b5M, related to the cited inhibitor, acarbose (IC<jats:sub>50<\/jats:sub> = 3.86 \u00b5M). Further, molecular docking studies of the most active compounds were carried out, and the results demonstrated considerable binding modes in the active site of\u00a0the\u00a0human lysosomal acid\u2010alpha\u2010glucosidase enzyme. In addition, the density functional theory was carried out to predict the electronic properties of active ligands. Structure\u2010activity relationship analysis implied that the electron\u2010leaving functions at the <jats:italic>para<\/jats:italic> position account for the variable enzyme inhibition. Therefore, developing novel therapeutic agents may assist as structural models in exploring diabetes mellitus.<\/jats:p>","DOI":"10.1002\/cbdv.202500040","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:37:16Z","timestamp":1748381836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis and Alpha\u2010glucosidase Inhibitory Effect of Pyrazole\u20101,2,3\u2010Triazole Hybrids"],"prefix":"10.1002","author":[{"given":"Suprapaneni","family":"Sirisha","sequence":"first","affiliation":[{"name":"Department of Chemistry, GITAM School of Sciences GITAM University  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraju","family":"Kerru","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Sciences GITAM University  Bengaluru India"},{"name":"School of Chemistry &amp; Physics University of 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