{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:57:53Z","timestamp":1755226673815,"version":"3.43.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to synthesize novel triazino[4,3\u2010<jats:italic>a<\/jats:italic>]quinolinecarboxylate compounds (<jats:bold>4<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>8<\/jats:bold>, and <jats:bold>10<\/jats:bold>) and evaluate these compounds for their antifungal activity against <jats:italic>Candida<\/jats:italic> species. Compound <jats:bold>8<\/jats:bold> was a standout candidate which demonstrated superior efficacy against <jats:italic>C. albicans<\/jats:italic> (minimum inhibitory concentration [MIC] = 45\u00a0\u00b5g\/mL), <jats:italic>C. glabrata<\/jats:italic> (MIC = 32\u00a0\u00b5g\/mL), <jats:italic>C. parapsilosis<\/jats:italic> (MIC = 36\u00a0\u00b5g\/mL) and <jats:italic>C. guilliermondii<\/jats:italic> (MIC = 32\u00a0\u00b5g\/mL) compared to Miconazole (MIC = 50\u201060\u00a0\u00b5g\/mL). Furthermore, the induced morphological and ultra\u2010structural changes by compound <jats:bold>8<\/jats:bold> on <jats:italic>Candida<\/jats:italic> cells are analyzed by light and transmission electron microscopy. Significant alterations in the viability and the architecture of <jats:italic>Candida<\/jats:italic> cells highlight the potential of compound <jats:bold>8<\/jats:bold> as a lead for further use as an antifungal drug. SARs displayed that substitution with the cyano group (as in compounds <jats:bold>8<\/jats:bold> and <jats:bold>10<\/jats:bold>) was critical for anticandida potency. A molecular docking study of the most active compounds <jats:bold>8<\/jats:bold> and <jats:bold>10<\/jats:bold> was conducted inside 14<jats:italic>\u03b1<\/jats:italic>\u2010demethylase (CYP51) to predict the binding mode of these compounds as antifungal. The most active compound <jats:bold>8<\/jats:bold> (MIC = 32\u201045\u00a0\u00b5g\/mL) demonstrated the highest binding energy score which is equal to \u20108.93\u00a0kcal\/mol. The findings of the in vitro anticandidal potential have been supported by molecular docking studies.<\/jats:p>","DOI":"10.1002\/cbdv.202500045","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T18:24:31Z","timestamp":1742322271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Evaluating the Anticandidal Activities of Triazino[4,3\u2010<i>a<\/i>]Quinolinecarboxylate Derivatives: A Promising Approach to Combat <i>Candida<\/i> Infections"],"prefix":"10.1002","author":[{"given":"Shaima M. N.","family":"Moustafa","sequence":"first","affiliation":[{"name":"Biology Department, College of Science Jouf University  Sakaka Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia A. 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