{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:14:47Z","timestamp":1784805287148,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973458"],"award-info":[{"award-number":["81973458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474148"],"award-info":[{"award-number":["82474148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Sanguisorba officinalis<\/jats:italic> L. (Di\u2010Yu in Chinese) is a traditional herbal plant that belongs to the genus <jats:italic>Sanguisorba<\/jats:italic> (Rosaceae). Four new bisabolane\u2010type sesquiterpenoids (<jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>) and two known monoterpenoids (<jats:bold>5<\/jats:bold> and <jats:bold>6<\/jats:bold>) were isolated from the roots of <jats:italic>S. officinalis<\/jats:italic>. Their structures were identified by nuclear magnetic resonance (NMR) spectra, high\u2010resolution electrospray ionization mass spectroscopy (HRESIMS), density functional theory (DFT) NMR calculations, and electronic circular dichroism (ECD) spectroscopic analysis. All compounds were isolated from the Rosaceae family for the first time. In addition, all the isolated compounds were evaluated for their anti\u2010melanogenic effects in vitro on IBMX\u2010stimulated B16F10 melanoma cells. The result showed that compounds <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>5<\/jats:bold> possessed moderately anti\u2010melanogenic effects at a concentration of 50\u00a0\u00b5M, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202500077","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:14:17Z","timestamp":1741932857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Four New Bisabolane\u2010Type Sesquiterpenoids From <i>Sanguisorba officinalis<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4513-9790","authenticated-orcid":false,"given":"Longlong","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Pharmacy The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-6086","authenticated-orcid":false,"given":"Liuqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1142\/S0192415X17500136","article-title":"Traditional Uses, Chemical Constituents and Biological Activities of Plants From the Genus Sanguisorba L.","volume":"45","author":"Zhao Z.","year":"2017","journal-title":"American Journal of Chinese Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bmcl.2018.04.033","article-title":"Anti\u2010Allergic Inflammatory Components From Sanguisorba officinalis L.","volume":"28","author":"Su X. 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