{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:07:30Z","timestamp":1773515250126,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The current study first describes the chemical profiles of essential oils from Vietnamese\n                    <jats:italic>Chromolaena odorata<\/jats:italic>\n                    fresh stem barks and leaves. The gas chromatography\u2010flame ionization detection\/mass spectrometry (GC\u2010FID\/MS) analysis revealed that \u03b1\u2010pinene (6.97%\u201338.91%), \u03b2\u2010pinene (5.68%\u201311.64%), geijerene (10.60%\u201326.68%), germacrene D (9.33%\u201316.87%), and (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010caryophyllene (5.03%\u20139.12%) were the major compounds. Essential oils showed strong anti\u2010inflammation against NO (nitric oxidative) production in lipopolysaccharide (LPS)\u2010stimulated RAW264.7 cells with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 42.44\u201349.01\u00a0\u00b5g\/mL. Two essential oils also exhibited cytotoxicity against four cancer cell lines, K562, HeLa, HepG2, and MCF\u20107, antioxidant activity to capture DPPH radicals, and antidiabetics in \u03b1\u2010glucosidase inhibition. Both samples showed varying levels in the antimicrobial experiment, especially the leaf essential oil, which showed strong antibacterial activity against the bacterium\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    with a MIC value of 64\u00a0\u00b5g\/mL. From the molecular docking investigation, geijerene had a higher affinity for cyclooxygenase\u20102 (COX\u20102) than the other main compounds, whereas germacrene D had the strongest binding affinity for two protein targets, COX\u20102, and\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    FtsZ. It was discovered that the main factor stabilizing the bindings of these compounds to the target proteins was hydrophobic interactions.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500091","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T08:58:28Z","timestamp":1737709108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Essential Oils From\n                    <i>Chromolaena odorata<\/i>\n                    (L.) R. M. King and H. Robinson Stem Barks and Leaves: Chemical Analysis, Biological Activity and In Silico Approach"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-6565","authenticated-orcid":false,"given":"Vu Minh","family":"Trang","sequence":"first","affiliation":[{"name":"VNU University of Education Vietnam National University  144 Xuan Thuy Caugiay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninh The","family":"Son","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Caugiay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Dinh","family":"Luyen","sequence":"additional","affiliation":[{"name":"Institute of Natural Products Chemistry Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Caugiay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Minh","family":"Giang","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, VNU University of Science Vietnam National University  19 Le Thanh Tong Hoankiem Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-024-03057-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/phrev.phrev_53_16"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6133"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(11)60189-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300386d"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.1373"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA19199H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/195057"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410500462678"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-474X(00)00011-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2020.1867009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2011.10643597"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070651"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.59.129"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.52225\/narra.v3i3.326"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.177200"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.06.038"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856005774649386"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2155699"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-019-0115-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/913\/1\/012092"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5897\/JPP2014.0309"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201200025"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.6.4.6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199310001-00006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.93"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2024.2398675"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13172506"},{"key":"e_1_2_8_30_1","first-page":"1","article-title":"Essential oil Compositions and Antimicrobial Activities of Syzygium fluviatile (Hemsl.) 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