{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:21:19Z","timestamp":1785450079351,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim was to investigate any cardioprotective potential of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) released by oil extracted from\n                    <jats:italic>Parkia speciosa<\/jats:italic>\n                    Hassk. seeds (\n                    <jats:italic>Ps<\/jats:italic>\n                    H). To achieve this, an in vivo heart failure model in Wistar rats was induced by daily administration of isoproterenol (ISO, 5\u00a0mg\/kg) for a week. In preliminary experiments, three organocyclic polysulfide H\n                    <jats:sub>2<\/jats:sub>\n                    S donors (1,2,4\u2010trithiolane, 1,3,5\u2010trithiane, and 1,2,4,6\u2010tetrathiepane) were identified in\n                    <jats:italic>Ps<\/jats:italic>\n                    H by gas chromatography\u2010mass spectrometry, then the in vitro 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl assay verified antioxidant activity for\n                    <jats:italic>Ps<\/jats:italic>\n                    H. In the heart failure model, markers of cardiac damage, lipids, and antioxidants plus urinary and serum H\n                    <jats:sub>2<\/jats:sub>\n                    S were measured, and cardiac tissues were also histopathologically scrutinized. In vivo,\n                    <jats:italic>Ps<\/jats:italic>\n                    H restored ISO\u2010suppressed serum and urinary H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and reversed ISO\u2010elevation of: the serum lipid profile (total cholesterol, triglycerides, and low\u2010density lipoprotein), cardiac oxidative stress (using malondialdehyde, superoxide dismutase, and reduced glutathione), and serum markers of cardiac damage (lactate dehydrogenase, creatine kinase\u2010myocardial band, and troponin\u20101). The findings were supported by histopathology (\n                    <jats:italic>Ps<\/jats:italic>\n                    H reversed ISO\u2010induced Zenker's type tissue degeneration and hemorrhage) along with congruent activities of three positive controls (sodium hydrosulfide, vitamin C, and digitalis). It was concluded that\n                    <jats:italic>Ps<\/jats:italic>\n                    H has the potential as an H\n                    <jats:sub>2<\/jats:sub>\n                    S donating nutraceutical in reducing biochemical aspects of heart failure.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500094","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T21:40:31Z","timestamp":1752356431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Polysulfide Containing Medicinal Plant\n                    <i>Parkia speciosa<\/i>\n                    \u00a0Hassk. has Both Antioxidant and Cardioprotective Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Ammara","family":"Asif","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy The Islamia University of Bahawalpur Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9324-3657","authenticated-orcid":false,"given":"Fiaz\u2010ud\u2010Din","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy The Islamia University of Bahawalpur Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi A.","family":"Mothana","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan M.","family":"Al\u2010Yousef","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D. E.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Cardiff School of Pharmacy and Pharmaceutical Science Cardiff University Cardiff UK"},{"name":"Department of Pharmacy CECOS University Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.068"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-019-0304-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_2_9_5_1","first-page":"4109","article-title":"Growth differentiation factor 11 is involved in isoproterenol\u2011induced heart failure","volume":"19","author":"Zhang X. 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