{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:57:31Z","timestamp":1780066651449,"version":"3.54.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this work, the phytochemical profile of\n                    <jats:italic>Cardamine raphanifolia<\/jats:italic>\n                    subsp.\n                    <jats:italic>acris<\/jats:italic>\n                    extracts were analyzed, and the total phenolic\/flavonoid content was evaluated using spectrophotometric methods. The highest phenolic content was found in butanol extracts (ButE), while the highest flavonoid content was detected in chloroform extracts (ChrE). GC\u2010MS analysis identified 32 compounds, such as\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexadecanoic acid in ethyl acetate (EtcE). The antioxidant activities of the extracts were confirmed through 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl radical (DPPH) and ferric reducing antioxidant power (FRAP) assays, but their effectiveness was lower compared to gallic acid. In enzyme inhibition tests, the extracts demonstrated tyrosinase inhibitory effects ranging from 42.91% to 52.22% at 200\u00a0\u00b5g\/mL. As elastase inhibitors, EtcE and ChrE showed the highest potential, whereas no collagenase inhibition was detected. Cytotoxicity analysis revealed that ButE did not have a cytotoxic effect on the human keratinocyte (HaCaT) cell line. These findings demonstrate that\n                    <jats:italic>C. raphanifolia<\/jats:italic>\n                    has the potential to serve as a source for developing skin health and antiaging agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500133","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T01:44:31Z","timestamp":1745286271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical Analysis, Antioxidant, Enzyme Inhibitory, and Cytotoxicity Properties of\n                    <i>Cardamine raphanifolia<\/i>\n                    subsp.\n                    <i>acris<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Nurdan","family":"Yazici","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can \u00d6zg\u00fcr","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7e","family":"Seyhan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin Altun","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Bo\u011fu\u015flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehlika","family":"Duru","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beg\u00fcm","family":"Bozalan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nese Ular","family":"\u00c7a\u011fatay","sequence":"additional","affiliation":[{"name":"Altium International Laboratory A.\u015e. 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