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As a result, research has intensified on products with direct antimicrobial effects or as adjuvants to antibiotics and antifungals. Products from stingless bees of the\n                    <jats:italic>Melipona<\/jats:italic>\n                    genus have shown biological properties, such as antimicrobial activity. This study evaluated the ethanolic extracts of geopropolis (EEGMq), wax (EEWMq), and pollen (EEPMq) from\n                    <jats:italic>Melipona quinquefasciata<\/jats:italic>\n                    (\u201cUru\u00e7u\u2010do\u2010ch\u00e3o\u201d) against multiresistant strains of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    10,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    06,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    24, and\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. The extracts were characterized by high\u2010performance liquid chromatography\u2010diode array detection, and antimicrobial activity was assessed through broth microdilution and plate subculture methods. Phenolic compounds identified in EEGMq included\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid, ferulic acid, naringenin, and apigenin. The extracts did not show significant direct antibacterial activity; however, there was potentiation of the antibiotic action when combined with Norfloxacin, Amikacin, and Penicillin against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and potentiation of Amikacin and Penicillin against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    . EEGMq also exhibited antifungal activity, significantly reducing Fluconazole activity against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . The results suggest that\n                    <jats:italic>M. quinquefasciata<\/jats:italic>\n                    extracts, especially geopropolis, hold promise for enhancing antibiotics and antifungals and contain bioactive molecules that modulate biological activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500134","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:23:31Z","timestamp":1753255411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic Compound Profile, Antimicrobial Activity, and Adjuvant Potential of Ethanolic Extracts From Bioproducts of\n                    <i>Melipona quinquefasciata<\/i>\n                    (Lepeletier, 1836)"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-0241","authenticated-orcid":false,"given":"Suieny Rodrigues","family":"Bezerra","sequence":"first","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato Brazil"},{"name":"Postgraduate Program in Biological Chemistry Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Henrique","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato Brazil"},{"name":"Postgraduate Program in Biological Chemistry Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rodrigues dos Santos Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato 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Teixeira","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nair Silva","family":"Mac\u00eado","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato Brazil"},{"name":"Postgraduate Program in Biological Chemistry Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zildene de Sousa","family":"Silveira","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospecting of the Semi\u2010Arid and Alternative Methods Regional University of Cariri \u2013 URCA  Crato Brazil"},{"name":"Postgraduate Program in Biological Sciences Federal University of Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa","family":"Guilhermino dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Mycology of Cariri Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alicy Neres","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Mycology of Cariri Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Od\u00edlia Duarte","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products Research Regional University of Cariri \u2013 URCA  Crato Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Datiane de Morais","family":"Oliveira\u2010Tintino","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology Regional 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