{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:03:46Z","timestamp":1773014626368,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401680"],"award-info":[{"award-number":["32401680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278071"],"award-info":[{"award-number":["22278071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Adhesive patches are optimum candidates for distinct biomedical applications, including tissue adhesion and leakage sealing in outpatient or surgical procedures. Unfortunately, most adhesive patches are significantly less effective at providing strong adhesion to the surface of wet tissue, which increases the risk and reduces the fault tolerance in surgery. Meanwhile, customization is difficult to achieve in terms of mechanical adaptability. To tackle this problem, we developed a chitosan\u2010containing bioadhesive patch (ANC) comprising dual\u2010crosslinked carboxymethyl chitosan methacrylate (CMCS\u2010MA), acrylic acid, and acrylic acid\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxysuccinimide ester. This ingenious and convenient design strategy facilitates the integrated polymerization of the patch, while circumventing the necessity for additional crosslinkers. ANC patches in dry state and the rich carboxyl groups contained therein enable rapid removal of moisture from tissue surfaces. Subsequently, robust adhesion based on hydrogen bonding and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxysuccinimide (NHS)\u2010amine interaction is formed. The dual\u2010crosslinked ANC patch achieves good adjustable mechanical performance and swelling behavior by controlling the addition of CMCS\u2010MA. Furthermore, compared with commercially available fibrin glue, ANC patches own robust adhesion and superior sealing performance for stomach fluid leakage. This intricately designed ANC patch sheds new light on biomedical patch design and broadens the scope of chitosan\u2010containing materials in tissue adhesive and sealant applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500139","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T03:49:33Z","timestamp":1745639373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Chitosan\u2010Containing Dual\u2010Crosslinked Resilient Patch for Tissue Adhesive and Sealant"],"prefix":"10.1002","volume":"22","author":[{"given":"Jiayu","family":"Yang","sequence":"first","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengchang","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou Fujian P. R. China"},{"name":"National Forestry and Grassland Administration Key Laboratory of Plant Fiber Functional Materials Fuzhou Fujian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1710-5"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01200"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00802-0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6362"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00798"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009189"},{"key":"e_1_2_8_5_2","first-page":"114","article-title":"Advances in Cellulose Nanofiber Hydrogels for Self\u2010powered wearable Pressure Sensors","volume":"9","author":"Zhu M.","year":"2024","journal-title":"Journal of Forestry Engineering"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129329"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai7466"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300394"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00813K"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2024.101792"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122936"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120555"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201805964"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124641"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304676"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155552"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c02089"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh2857"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006389117"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-024-05762-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.04.098"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115970"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.017"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00236-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202202285"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c01199"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-024-06166-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.05.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.034"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00498"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212015"}],"container-title":["Chemistry &amp; 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